Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.
Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.
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DOI：
10.1093/infdis/jiy317
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发表时间：
2018-09-08
期刊：
影响因子：
--
通讯作者：
Mok CKP
中科院分区：
文献类型：
--
作者：
Guan W;Yang Z;Wu NC;Lee HHY;Li Y;Jiang W;Shen L;Wu DC;Chen R;Zhong N;Wilson IA;Peiris M;Mok CKP
本研究将禽流感A（H7N9）病毒感染患者的系列血液转录组学谱与患者的临床数据相关联。定义了与下呼吸道血氧和病毒载量相关的生物学显著性转录组学特征。禽流感A（H7N9）病毒于2013年在中国出现，并导致与30%以上的病死率相关的人畜共患疾病。外周血中的转录谱反映了宿主的反应，有助于阐明疾病的发病机制。我们关联了禽流感A（H7N9）病毒感染患者的系列血液转录组学谱，并从分析中确定了生物学意义。我们发现血液中的特定基因表达谱与Pao 2/Fio 2比值和下呼吸道中的病毒载量密切相关。细胞周期和白细胞相关的免疫在感染的急性期被激活，而T细胞功能和各种代谢过程与疾病的恢复阶段有关。我们开发了一种新的转录组学分析方法，以确定与H7N9感染患者的特定临床和病毒学参数密切相关的关键宿主反应。
This study correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection with clinical data of patients. Biologically significant transcriptomic profiles associated with blood oxygenation and viral load in the lower respiratory tract were defined. Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
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