The Unstable Atherosclerotic Plaque: Clinical Significance and Therapeutic Intervention

The Unstable Atherosclerotic Plaque: Clinical Significance and Therapeutic Intervention
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不稳定的动脉粥样硬化斑块:临床意义和治疗干预

DOI:
10.1055/s-0038-1657534
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发表时间:
1997
影响因子:
6.7
通讯作者:
Y. Nemerson
Y. Nemerson
中科院分区:
医学2区
文献类型:
--
作者:
V. Fuster;J. Fallon;J. Badimón;Y. Nemerson

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我们对冠状动脉粥样硬化的病理生理学的认识在过去几年中发生了显著的变化。现在对动脉粥样硬化病变的类型、冠状动脉粥样硬化进展的机制(斑块不稳定和破裂)以及随后导致急性冠状动脉综合征的血栓形成现象有了更好的了解(1-3)。导致动脉粥样硬化病变稳定甚至消退的治疗策略,以及减轻或预防血栓性并发症的新的抗血栓形成策略正在被追求。本文就冠状动脉粥样硬化不稳定斑块及其并发血栓的研究进展作一综述。
Our knowledge of the pathophysiology of coronary atherosclerosis has remarkably changed in the last few years. The types of atherosclerotic lesions, the mechanisms of progression of coronary atherosclerosis with plaque instability and disruption, and the subsequent thrombotic phenomenon leading to acute coronary syndromes are now better understood (1-3). Therapeutic strategies leading to atherosclerotic lesion stabilization and even regression, as well as new antithrombotic strategies to alleviate or prevent the thrombotic complications are being pursued. This review focuses on the coronary unstable atherosclerotic plaque and complicatin g thrombosis.
DOI: 10.1172/jci117619
发表时间: 1994-12-01
影响因子: 15.9
作者:
GALIS, ZS;SUKHOVA, GK;LIBBY, P
通讯作者: LIBBY, P
通过结合地高辛标记的因子 VIIa 和 X,对人动脉粥样硬化斑块中的组织因子进行原位定位。
DOI: --
发表时间: 1996
期刊: Laboratory investigation; a journal of technical methods and pathology.
影响因子: --
作者:
Thiruvikraman,SV;Guha,A;Roboz,J;Taubman,MB;Nemerson,Y;Fallon,JT
通讯作者: Fallon,JT
DOI: 10.1161/01.atv.8.2.103
发表时间: 1988-03-01
期刊: ARTERIOSCLEROSIS
影响因子: --
作者:
SMALL, DM
通讯作者: SMALL, DM
DOI: 10.1161/01.cir.78.5.1157
发表时间: 1988-11-01
期刊: CIRCULATION
影响因子: 37.8
作者:
LITTLE, WC;CONSTANTINESCU, M;SANTAMORE, WP
通讯作者: SANTAMORE, WP
DOI: 10.1172/jci114558
发表时间: 1990-04-01
影响因子: 15.9
作者:
BADIMON, JJ;BADIMON, L;FUSTER, V
通讯作者: FUSTER, V