Hypoxic incubation at 50% of atmospheric levels shifts the cardiovascular response to acute hypoxia in American alligators, Alligator mississippiensis

Hypoxic incubation at 50% of atmospheric levels shifts the cardiovascular response to acute hypoxia in American alligators, Alligator mississippiensis
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缺氧%20孵化%20at%2050%%20of%20atmospheric%20levels%20shifts%20the%20心血管%20反应%20至%20急性%20缺氧%20in%20American%20alligators,%20Alligator%20mississippiensis

DOI:
10.1007/s00360-023-01510-8
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发表时间:
2023
期刊:
Journal of Comparative Physiology B
影响因子:
--
通讯作者:
Crossley, Dane A.
Crossley, Dane A.
中科院分区:
--
文献类型:
--
作者:
Crossley, Janna L.;Smith, Brandt;Tull, Melissa;Elsey, Ruth M.;Wang, Tobias;Crossley, Dane A.

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我们设计了一系列的研究,以调查是否缺氧(10%O2)从20%的孵化到孵化,或从20至50%的孵化,影响心血管功能时,少年美洲短吻鳄达到4-5岁的少年相比,在21%O2孵化。在这个年龄段,我们测量了所有主要动脉的血流量,以及在常氧和急性缺氧(10%O2和5%O2)的动物的心率,血压和血气。在所有三个组中,暴露于10%O2的急性缺氧引起血液中O2浓度的降低和4-5岁动物心率的增加,对心脏主要流出血管的血流影响有限。在更急性缺氧(5%O2)时,血液O2浓度进一步降低,我们测量到右主动脉、锁骨下动脉、颈动脉和肺动脉的心率和血流量增加;然而,左主动脉的血流量减少或没有变化。胚胎暴露于缺氧增加的阈值引起的增加,心率的敏感性下降的指示。在低氧环境中培养的短吻鳄在常氧环境中也有较高的动脉PCO 2值,这表明相对于代谢,通气量减少。
We designed a series of studies to investigate whether hypoxia (10% O2) from 20% of incubation to hatching, or from 20 to 50% of incubation, affects cardiovascular function when juvenile American alligators reached an age of 4–5 years compared to juveniles that were incubated in 21% O2. At this age, we measured blood flows in all the major arteries as well as heart rate, blood pressure, and blood gases in animals in normoxia and acute hypoxia (10% O2and 5% O2). In all three groups, exposure to acute hypoxia of 10% O2caused a decrease in blood O2concentration and an increase in heart rate in 4–5-year-old animals, with limited effects on blood flow in the major outflow vessels of the heart. In response to more acute hypoxia (5% O2), where blood O2concentration decreased even further, we measured increased heart rate and blood flow in the right aorta, subclavian artery, carotid artery, and pulmonary artery; however, blood flow in the left aorta either decreased or did not change. Embryonic exposure to hypoxia increased the threshold for eliciting an increase in heart rate indicative of a decrease in sensitivity. Alligators that had been incubated in hypoxia also had higher arterial PCO2values in normoxia, suggesting a reduction in ventilation relative to metabolism.
美洲短吻鳄胚胎时期心血管对缺氧的敏感性(密西西比短吻鳄)。
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