Hypoxic incubation at 50% of atmospheric levels shifts the cardiovascular response to acute hypoxia in American alligators, Alligator mississippiensis
Hypoxic incubation at 50% of atmospheric levels shifts the cardiovascular response to acute hypoxia in American alligators, Alligator mississippiensis
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缺氧%20孵化%20at%2050%%20of%20atmospheric%20levels%20shifts%20the%20心血管%20反应%20至%20急性%20缺氧%20in%20American%20alligators,%20Alligator%20mississippiensis
DOI:
10.1007/s00360-023-01510-8
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发表时间:
2023
期刊:
影响因子:
--
通讯作者:
Crossley, Dane A.
中科院分区:
文献类型:
--
作者:
Crossley, Janna L.;Smith, Brandt;Tull, Melissa;Elsey, Ruth M.;Wang, Tobias;Crossley, Dane A.
We designed a series of studies to investigate whether hypoxia (10% O2) from 20% of incubation to hatching, or from 20 to 50% of incubation, affects cardiovascular function when juvenile American alligators reached an age of 4–5 years compared to juveniles that were incubated in 21% O2. At this age, we measured blood flows in all the major arteries as well as heart rate, blood pressure, and blood gases in animals in normoxia and acute hypoxia (10% O2and 5% O2). In all three groups, exposure to acute hypoxia of 10% O2caused a decrease in blood O2concentration and an increase in heart rate in 4–5-year-old animals, with limited effects on blood flow in the major outflow vessels of the heart. In response to more acute hypoxia (5% O2), where blood O2concentration decreased even further, we measured increased heart rate and blood flow in the right aorta, subclavian artery, carotid artery, and pulmonary artery; however, blood flow in the left aorta either decreased or did not change. Embryonic exposure to hypoxia increased the threshold for eliciting an increase in heart rate indicative of a decrease in sensitivity. Alligators that had been incubated in hypoxia also had higher arterial PCO2values in normoxia, suggesting a reduction in ventilation relative to metabolism.
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DOI:
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