A-to-I RNA editing does not change with age in the healthy male rat brain.
A-to-I RNA editing does not change with age in the healthy male rat brain.
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DOI：
10.1007/s10522-013-9433-8
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发表时间：
2013-08
期刊：
影响因子：
4.5
通讯作者：
de Magalhaes, Joao Pedro
中科院分区：
文献类型：
--
作者：
Holmes, Andrew P.;Wood, Shona H.;Merry, Brian J.;de Magalhaes, Joao Pedro
RNA编辑是一种转录后过程，其导致对RNA的碱基取代修饰。它是通过氨基酸取代和剪接事件的调节产生蛋白质多样性的重要过程。先前的研究表明，腺苷到肌苷RNA编辑的基因特异性减少与人脑衰老之间存在联系。在这里，我们证明了在人类中观察到的RNA编辑随年龄的变化在健康大鼠的衰老过程中没有观察到。此外，我们确定了一个保守的编辑网站在大鼠，在Cog 3。我们认为，RNA编辑中与年龄相关的变化是灵长类动物或人类特有的，或者它们是疾病病理学的表现。由于啮齿动物经常被用作研究衰老的模型生物，这些发现表明了理解衰老过程中RNA生物学中物种特异性差异的重要性。本文的在线版本（doi：10.1007/s10522-013-9433-8）包含补充材料，可供授权用户使用。
RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events. Previous studies have suggested a link between gene-specific reductions in adenosine to inosine RNA editing and aging in the human brain. Here we demonstrate that changes in RNA editing observed in humans with age are not observed during aging in healthy rats. Furthermore, we identify a conserved editing site in rats, in Cog3. We propose that either age-related changes in RNA editing are specific to primates or humans, or that they are the manifestation of disease pathology. Since rodents are often used as model organisms for studying aging, these findings demonstrate the importance of understanding species-specific differences in RNA biology during aging. The online version of this article (doi:10.1007/s10522-013-9433-8) contains supplementary material, which is available to authorized users.
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通过超高通量测序对精神疾病中集中的 a-to-I RNA 编辑位点进行定量分析。
影响因子：
3.7
作者：
Zhu H;Urban DJ;Blashka J;McPheeters MT;Kroeze WK;Mieczkowski P;Overholser JC;Jurjus GJ;Dieter L;Mahajan GJ;Rajkowska G;Wang Z;Sullivan PF;Stockmeier CA;Roth BL
通讯作者：
Roth BL
影响因子：
4.5
作者：
Shestakova, A;Zolov, S;Lupashin, V
通讯作者：
Lupashin, V
DOI：
10.1073/pnas.1222878110
发表时间：
2013-02-26
影响因子：
11.1
作者：
Seok, Junhee;Warren, H. Shaw;Tompkins, Ronald G.
通讯作者：
Tompkins, Ronald G.
影响因子：
11.4
作者：
Eisenberg, E;Nemzer, S;Levanon, EY
通讯作者：
Levanon, EY
影响因子：
12.3
作者：
Danecek P;Nellåker C;McIntyre RE;Buendia-Buendia JE;Bumpstead S;Ponting CP;Flint J;Durbin R;Keane TM;Adams DJ
通讯作者：
Adams DJ