Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis.
Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis.
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DOI：
10.1016/j.jcin.2011.05.025
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发表时间：
2011-10
影响因子：
11.3
通讯作者：
Simon, Daniel I.
中科院分区：
文献类型：
--
作者：
Inoue, Teruo;Croce, Kevin;Morooka, Toshifumi;Sakuma, Masashi;Node, Koichi;Simon, Daniel I.
控制PCI后血管损伤反应的细胞和分子过程涉及控制动脉重塑、新生内膜增殖和再内皮化的血管细胞和祖细胞之间的复杂相互作用。药物洗脱支架（DES）通过调节血管炎症和防止新生内膜增生和再狭窄来提高经皮冠状动脉介入治疗（PCI）的疗效。尽管DES的积极作用可以减少炎症和再狭窄，但负面作用会延迟再内皮化并损害内皮功能。延迟再内皮化和内皮功能受损可能与支架血栓形成和DES使用后的不良临床结局有关。与BMS相比，DES对血管祖细胞的动员、归巢和分化也有不同的调节作用，涉及血管再内皮化和新生内膜增殖。DES对血管炎症和修复的影响直接影响这些器械的临床结局，并要求延长双联抗血小板治疗的持续时间。
The cellular and molecular processes that control vascular injury responses following PCI involve a complex interplay among vascular cells and progenitor cells that control arterial remodeling, neoinitimal proliferation and reendothelialization. Drug eluting stents (DES) improve the efficacy of peructaneous coronary intervention (PCI) by modulating vascular inflammation and preventing neointimal proliferation and restenosis. Although positive effects of DES reduce inflammation and restenosis, negative effects delay reendothelialization and impair endothelial function. Delayed reendothelialization and impaired endothelial function may be linked to stent thrombosis and adverse clinical outcomes following DES use. Compared with BMS, DES may also differentially modulate mobilization, homing and differentiation of vascular progenitor cells involved reendothelialization and neointimal proliferation. The effects of DES on vascular inflammation and repair directly impact clinical outcomes with these devices and dictate requirements for extended duration dual antiplatelet therapy.
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