Restoration of motor control and proprioceptive and cutaneous sensation in humans with prior upper-limb amputation via multiple Utah Slanted Electrode Arrays (USEAs) implanted in residual peripheral arm nerves.
Restoration of motor control and proprioceptive and cutaneous sensation in humans with prior upper-limb amputation via multiple Utah Slanted Electrode Arrays (USEAs) implanted in residual peripheral arm nerves.
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DOI：
10.1186/s12984-017-0320-4
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发表时间：
2017-11-25
影响因子：
5.1
通讯作者：
Clark GA
中科院分区：
文献类型：
--
作者：
Wendelken S;Page DM;Davis T;Wark HAC;Kluger DT;Duncan C;Warren DJ;Hutchinson DT;Clark GA
尽管先进的机器人手，直观的控制和感官反馈，这些假肢已被限制到只有3度的自由度（DOF）与2个感官知觉的闭环控制。犹他州倾斜电极阵列（USEA）过去已被用于为人类截肢者提供多达81个感官知觉。在这里，我们报告了植入人类截肢者残余外周臂神经中的多个USEA的先进功能，用于恢复对5个自由度的控制和多达131个本体感觉和皮肤手部感觉感知的感觉。我们还证明，USEA恢复的感官知觉在闭环虚拟假手控制期间提供了有用的反馈来源。两个100通道USEA植入4-5周，分别植入两名既往长时间上臂截肢的人类受试者的正中和尺臂神经中。通过修改后的卡尔曼滤波器从神经元放电模式中解码出预期的手指和手腕位置，使受试者能够控制虚拟假手的许多动作。此外，USEA微刺激被用来唤起许多感官知觉跨越幻手。闭环控制通过尺神经USEA的电极刺激实现，同时通过正中神经USEA记录和解码运动。受试者控制多达12度的自由，在非正式的，“自由形式”的在线运动解码会议，并经历了多达131个USEA诱发的本体感觉和皮肤感觉跨越幻手。实现了5自由度实时解码的独立控制，包括拇指、食指、中指和无名指以及手腕的屈曲/伸展。实现了4自由度实时解码的比例控制。一名受试者使用USEA诱发的手部感觉作为反馈来完成1-DOF闭环虚拟手部运动任务。未观察到USEA植入物导致的长期功能缺陷。高通道数USEA的植入能够实现虚拟假手运动的多自由度控制，并在植入后短短4-5周内恢复跨越手部的本体感受和皮肤感觉感知的丰富选择。未来USEA在长期植入物和闭环中的使用可能会恢复完整手的许多功能，同时有助于假体的有意义的实施。本文的在线版本（10.1186/s12984-017-0320-4）包含补充材料，可供授权用户使用。
Despite advances in sophisticated robotic hands, intuitive control of and sensory feedback from these prostheses has been limited to only 3-degrees-of-freedom (DOF) with 2 sensory percepts in closed-loop control. A Utah Slanted Electrode Array (USEA) has been used in the past to provide up to 81 sensory percepts for human amputees. Here, we report on the advanced capabilities of multiple USEAs implanted in the residual peripheral arm nerves of human amputees for restoring control of 5 DOF and sensation of up to 131 proprioceptive and cutaneous hand sensory percepts. We also demonstrate that USEA-restored sensory percepts provide a useful source of feedback during closed-loop virtual prosthetic hand control. Two 100-channel USEAs were implanted for 4–5 weeks, one each in the median and ulnar arm nerves of two human subjects with prior long-duration upper-arm amputations. Intended finger and wrist positions were decoded from neuronal firing patterns via a modified Kalman filter, allowing subjects to control many movements of a virtual prosthetic hand. Additionally, USEA microstimulation was used to evoke numerous sensory percepts spanning the phantom hand. Closed-loop control was achieved by stimulating via an electrode of the ulnar-nerve USEA while recording and decoding movement via the median-nerve USEA. Subjects controlled up to 12 degrees-of-freedom during informal, ‘freeform’ online movement decode sessions, and experienced up to 131 USEA-evoked proprioceptive and cutaneous sensations spanning the phantom hand. Independent control was achieved for a 5-DOF real-time decode that included flexion/extension of the thumb, index, middle, and ring fingers, and the wrist. Proportional control was achieved for a 4-DOF real-time decode. One subject used a USEA-evoked hand sensation as feedback to complete a 1-DOF closed-loop virtual-hand movement task. There were no observed long-term functional deficits due to the USEA implants. Implantation of high-channel-count USEAs enables multi-degree-of-freedom control of virtual prosthetic hand movement and restoration of a rich selection of both proprioceptive and cutaneous sensory percepts spanning the hand during the short 4–5 week post-implant period. Future USEA use in longer-term implants and in closed-loop may enable restoration of many of the capabilities of an intact hand while contributing to a meaningful embodiment of the prosthesis. The online version of this article (10.1186/s12984-017-0320-4) contains supplementary material, which is available to authorized users.
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DOI：
10.1109/tnsre.2011.2162635
发表时间：
2011-10-01
影响因子：
4.9
作者：
Horch, Kenneth;Meek, Sanford;Hutchinson, Douglas T.
通讯作者：
Hutchinson, Douglas T.
影响因子：
2.5
作者：
Dhillon, GS;Krüger, TB;Horch, KW
通讯作者：
Horch, KW
影响因子：
4
作者：
Davis, T. S.;Wark, H. A. C.;Greger, B.
通讯作者：
Greger, B.
影响因子：
14
作者：
Christensen, Michael B.;Wark, Heather A. C.;Hutchinson, Douglas T.
通讯作者：
Hutchinson, Douglas T.
影响因子：
3
作者：
Gunalan, Kabilar;Warren, David J.;Clark, Gregory A.
通讯作者：
Clark, Gregory A.