Microelectrode Studies of Basal Ganglia and VA, VL and VP Thalamus in Patients With Dystonia: Dystonia-Related Activity and Somatic Sensory Reorganization
Microelectrode Studies of Basal Ganglia and VA, VL and VP Thalamus in Patients With Dystonia: Dystonia-Related Activity and Somatic Sensory Reorganization
复制标题
肌张力障碍患者基底神经节和 VA、VL 和 VP 丘脑的微电极研究:肌张力障碍相关活动和躯体感觉重组
DOI:
10.1007/978-1-4615-1235-6_19
复制
发表时间:
2001
影响因子:
5.1
通讯作者:
S. Hua
中科院分区:
文献类型:
--
作者:
F. Lenz;N. Byl;I. Garonzik;Jung I. Lee;S. Hua
Dystonia is a movement disorder characterized by sustained muscle contractions leading to twisting movements and abnormal postures (Fahn, 1988). It is usually assumed that dystonia is driven by abnormal activity arising in the basal ganglia (Marsden et al., 1985; Hallett, 1997; Vitek et al., 1998). Additionally, there is indirect evidence that neuronal activity in a cerebellar relay nucleus of the human thalamus (Ventral intermediate - Vim) and in a pallidal relay nucleus (Ventral oral posterior - Vop) is related to dystonic movements. Lesions in Vim and Vop relieve dystonia (Laitinen, 1970; Cooper, 1976; Gros et al., 1976; Andrew et al., 1983; Tasker et al., 1988b; Tasker et al., 1988a; Cardoso et al., 1995) and stimulation of Vim and Vop can increase (Tasker et al., 1982) or decrease dystonic movements (Benabid et al., 1996). The effects of thalamic lesioning and stimulation may be related to abnormalities in sensory processing observed in the central nervous system of patients with dystonia (Tempel and Perlmutter, 1990; Reilly et al., 1992; Tempel and Perlmutter, 1995).
影响因子:
14.5
作者:
LENZ, FA;KWAN, HC;LENZ, YE
通讯作者:
LENZ, YE
影响因子:
2.5
作者:
LENZ, FA;KWAN, HC;DOSTROVSKY, JO
通讯作者:
DOSTROVSKY, JO