Microelectrode Studies of Basal Ganglia and VA, VL and VP Thalamus in Patients With Dystonia: Dystonia-Related Activity and Somatic Sensory Reorganization

Microelectrode Studies of Basal Ganglia and VA, VL and VP Thalamus in Patients With Dystonia: Dystonia-Related Activity and Somatic Sensory Reorganization
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肌张力障碍患者基底神经节和 VA、VL 和 VP 丘脑的微电极研究:肌张力障碍相关活动和躯体感觉重组

DOI:
10.1007/978-1-4615-1235-6_19
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发表时间:
2001
影响因子:
5.1
通讯作者:
S. Hua
S. Hua
中科院分区:
医学3区
文献类型:
--
作者:
F. Lenz;N. Byl;I. Garonzik;Jung I. Lee;S. Hua

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肌张力障碍是一种运动障碍,其特征是持续的肌肉收缩导致扭曲的运动和不正常的姿势(Fahn,1988)。通常认为肌张力障碍是由基底节异常活动引起的(Marsden等人,1985;Hallett,1997;Vitek等人,1998)。此外,有间接证据表明,人类丘脑的小脑中继核(腹侧中间-Vim)和苍白球中继核(腹侧口腔后Vop)中的神经元活动与肌张力障碍运动有关。Vim和Vop的损伤可缓解肌张力障碍(Laitinen,1970;Cooper,1976;Gros等人,1976;Andrew等人,1983;Tasker等人,1988b;Tasker等人,1988 a;Cardoso等人,1995),并且Vim和Vop的刺激可以增加(Tasker等人,1982)或减少肌张力障碍运动(Benabid等人,1996)。丘脑损伤和刺激的影响可能与在肌张力障碍患者的中枢神经系统观察到的感觉处理异常有关(Tempel和Perlmutter,1990;Reilly等人,1992;Tempel和Perlmutter,1995)。
Dystonia is a movement disorder characterized by sustained muscle contractions leading to twisting movements and abnormal postures (Fahn, 1988). It is usually assumed that dystonia is driven by abnormal activity arising in the basal ganglia (Marsden et al., 1985; Hallett, 1997; Vitek et al., 1998). Additionally, there is indirect evidence that neuronal activity in a cerebellar relay nucleus of the human thalamus (Ventral intermediate - Vim) and in a pallidal relay nucleus (Ventral oral posterior - Vop) is related to dystonic movements. Lesions in Vim and Vop relieve dystonia (Laitinen, 1970; Cooper, 1976; Gros et al., 1976; Andrew et al., 1983; Tasker et al., 1988b; Tasker et al., 1988a; Cardoso et al., 1995) and stimulation of Vim and Vop can increase (Tasker et al., 1982) or decrease dystonic movements (Benabid et al., 1996). The effects of thalamic lesioning and stimulation may be related to abnormalities in sensory processing observed in the central nervous system of patients with dystonia (Tempel and Perlmutter, 1990; Reilly et al., 1992; Tempel and Perlmutter, 1995).
DOI: 10.1093/brain/113.6.1795
发表时间: 1990-12-01
期刊: BRAIN
影响因子: 14.5
作者:
LENZ, FA;KWAN, HC;LENZ, YE
通讯作者: LENZ, YE
DOI: 10.1152/jn.1994.72.4.1570
发表时间: 1994-10-01
影响因子: 2.5
作者:
LENZ, FA;KWAN, HC;DOSTROVSKY, JO
通讯作者: DOSTROVSKY, JO