The evolving definition of essential tremor: What are we dealing with?
The evolving definition of essential tremor: What are we dealing with?
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DOI：
10.1016/j.parkreldis.2017.07.004
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发表时间：
2018-01
影响因子：
4.1
通讯作者：
Louis ED
中科院分区：
文献类型：
--
作者：
Louis ED
虽然特发性震颤（ET）在临床实践中很常见，但从历史上看，对于如何最好地定义它一直存在相当大的分歧，现在随着对其临床复杂性的认识越来越多，如何最好地封装它。2017年6月19日进行的PubMed检索将“特发性震颤”与9个第二检索词交叉（例如，定义、诊断）。临床和诊断不确定性有几个主要问题。每个问题背后都有一个关于ET潜在病理生理学性质的更大问题。发病年龄有关系吗？ET中可接受的肌张力障碍程度是多少？多少程度的“小脑征”是可以接受的？非运动功能是由基础疾病引起的，还是仅仅继发于临床特征？ET是一个单一的疾病实体还是其他什么？我们正在更多地了解ET，作为这些努力的副产品，我们正在努力定义它。进一步了解潜在疾病发病机制的性质以及小脑和小脑中继在这一过程中发挥的作用可能会提供重要的线索，使我们能够为不确定的领域带来秩序。
Although essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty. A PubMed search conducted on June 19, 2017 crossed “essential tremor” with 9 second search terms (e.g., definition, diagnosis). There are several major issues of clinical and diagnostic uncertainty. Underlying each issue is a larger question about the nature of the underlying pathophysiology of ET. Does age of onset of ET matter? How much dystonia is acceptable in ET? How much in the way of “cerebellar signs” are acceptable? Are non-motor features due to the underlying disease or merely secondary to the clinical features? Is ET a single disease entity or something else? We are learning more about ET and, as a by-product of these efforts, are struggling with its definition. Further understanding the nature of the underlying disease pathogenesis as well as the role the cerebellum and cerebellar relays play in this process will likely provide important clues to enable us to bring order to areas of uncertainty.
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影响因子：
5.1
作者：
Louis, E. D.;Benito-Leon, J.;Bermejo-Pareja, F.
通讯作者：
Bermejo-Pareja, F.
影响因子：
3.5
作者：
Kim, Young Eun;Kim, Ji Soo;Jeon, Beom S.
通讯作者：
Jeon, Beom S.
影响因子：
14.5
作者：
Stolze, H;Petersen, G;Deuschl, G
通讯作者：
Deuschl, G
影响因子：
8.6
作者：
Hopfner, Franziska;Ahlf, Anjuli;Deuschl, Guenther
通讯作者：
Deuschl, Guenther
影响因子：
2
作者：
Jhunjhunwala, Ketan;Netravathi, M.;Pal, Pramod Kumar
通讯作者：
Pal, Pramod Kumar