Cell-Cell Fusion Mediated by Viruses and HERV-Derived Fusogens in Cancer Initiation and Progression.
Cell-Cell Fusion Mediated by Viruses and HERV-Derived Fusogens in Cancer Initiation and Progression.
复制标题
DOI：
10.3390/cancers13215363
复制
发表时间：
2021-10-26
期刊：
影响因子：
5.2
通讯作者：
Hass R
中科院分区：
文献类型：
--
作者：
Dittmar T;Weiler J;Luo T;Hass R
尽管已经知道(癌症)细胞可以融合，但(癌症)细胞如何合并它们的质膜，从而产生双核和多核杂交细胞，人们仍然知之甚少。细胞-细胞融合是一个能量依赖的过程，而所谓的融合原是一种关键的膜结合蛋白，它是克服质膜杂交与相关的能量障碍所必需的。病毒和人类内源性逆转录病毒元件的融合原是融合颗粒和蛋白质的天然储存库，可能导致癌细胞双核和多核。同样，在由致癌病毒引起的几种癌症中也发现了多核巨型癌细胞，这表明病毒与人类内源性逆转录病毒来源的融合原在癌细胞融合中可能存在相关性。细胞融合是一种众所周知但仍鲜为人知的生物学现象，它可能在癌症的发生、发展和转移的形成中发挥作用。尽管两个(癌症)细胞的合并看起来很简单，但整个过程非常复杂，依赖能量，并且受到严格的监管。在细胞融合诱导和调节因子中，所谓的融合原被认为是一种特定类型的蛋白质，对于克服融合相关的能量障碍和质膜的最终合并是必不可少的。大约8%的人类基因组来自逆转录病毒，一些众所周知的融合蛋白，如合胞素-1，是由人类(癌症)细胞表达的。同样，包膜病毒可以通过进化优化的融合子实现和促进细胞融合，也能够诱导双核和多核突出它们的融合能力。此外，在致癌病毒衍生的肿瘤中也发现了多核巨型癌细胞。因此，本文将对内源性逆转录病毒来源的病毒与融合因子在癌细胞融合中的潜在相关性进行综述。
Even though it is known that (cancer) cells can fuse, it is still less understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi- and multinucleated hybrid cells. Cell-cell fusion is an energy-dependent process and so-called fusogens are a crucial type of membrane-bound proteins, which are mandatory for overcoming plasma membrane hybridization with associated energetic barriers. Viruses and fusogens of human endogenous retroviral elements are a natural reservoir of fusogenic particles and proteins that could cause bi- and multinucleation of cancer cells. Likewise, multinucleated giant cancer cells have been found in several cancers caused by oncogenic viruses suggesting a possible correlation between viruses and fusogens of human endogenous retroviral origin in cancer cell fusion. Cell fusion is a well-known, but still scarcely understood biological phenomenon, which might play a role in cancer initiation, progression and formation of metastases. Although the merging of two (cancer) cells appears simple, the entire process is highly complex, energy-dependent and tightly regulated. Among cell fusion-inducing and -regulating factors, so-called fusogens have been identified as a specific type of proteins that are indispensable for overcoming fusion-associated energetic barriers and final merging of plasma membranes. About 8% of the human genome is of retroviral origin and some well-known fusogens, such as syncytin-1, are expressed by human (cancer) cells. Likewise, enveloped viruses can enable and facilitate cell fusion due to evolutionarily optimized fusogens, and are also capable to induce bi- and multinucleation underlining their fusion capacity. Moreover, multinucleated giant cancer cells have been found in tumors derived from oncogenic viruses. Accordingly, a potential correlation between viruses and fusogens of human endogenous retroviral origin in cancer cell fusion will be summarized in this review.
登录
查看更多内容
影响因子：
4.7
作者：
Agoni L;Guha C;Lenz J
通讯作者：
Lenz J
影响因子：
5.6
作者：
Bojko A;Staniak K;Czarnecka-Herok J;Sunderland P;Dudkowska M;Śliwińska MA;Salmina K;Sikora E
通讯作者：
Sikora E
影响因子：
78.5
作者：
Bjerkvig, R;Tysnes, BB;Terzis, AJA
通讯作者：
Terzis, AJA
影响因子：
--
作者：
Adderson, Elisabeth;Branum, Kristen;Hurwitz, Julia L.
通讯作者：
Hurwitz, Julia L.
影响因子：
5.4
作者：
Abdullahi, Sarah;Jaekel, Melanie;Altomonte, Jennifer
通讯作者：
Altomonte, Jennifer