The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.
The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.
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DOI：
10.3389/fnagi.2021.773984
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发表时间：
2021
影响因子：
4.8
通讯作者：
Osorio RS
中科院分区：
文献类型：
--
作者：
Ramos-Cejudo J;Johnson AD;Beiser A;Seshadri S;Salinas J;Berger JS;Fillmore NR;Do N;Zheng C;Kovbasyuk Z;Ardekani BA;Bubu OM;Parekh A;Convit A;Betensky RA;Wisniewski TM;Osorio RS
目的：活跃的中性粒细胞是阿尔茨海默病（AD）病理的重要贡献者，通过形成毛细血管停滞，损害脑血流量（CBF），并通过异常的中性粒细胞信号促进疾病进展。中性粒细胞与淋巴细胞比率（NLR）是中性粒细胞介导炎症的一个指标，在临床诊断为AD的患者中发现更高的NLR。本研究的目的是调查老年人NLR的增加是否与随后痴呆的风险独立相关。方法：我们在社区为基础的弗雷明汉心脏研究（FHS）纵向队列中研究了基线NLR与痴呆发生风险的关系。使用累积发生率函数（CIF）和逆概率加权Cox比例原因特异性风险回归模型评估NLR与痴呆风险之间的关联，并调整年龄、性别、体重指数（BMI）、收缩压和舒张压、糖尿病、当前吸烟状况、低密度脂蛋白（LDH）、高密度脂蛋白（LDL）、总胆固醇、甘油三酯和心血管疾病史（CVD）。随机森林生存模型用于评估模型协变量对痴呆风险的相对预测值。结果：最终的研究样本包括1648名患有FHS的参与者（平均年龄69岁，56%为女性）。在随访期间（中位5.9年），我们观察到51例痴呆，其中41例为AD。加权模型的结果表明，NLR与痴呆事件独立相关，其预测价值仅与年龄、心血管疾病史和基线血压有关。结论：我们的研究表明，在5.9年的随访期间，NLR较高的个体随后发生痴呆的风险更大。进一步评估中性粒细胞介导的炎症在AD进展中的作用可能是有必要的。
Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is a proxy of neutrophil-mediated inflammation, and higher NLR is found in persons diagnosed with clinical AD. The objective of this study was to investigate whether increased NLR in older adults is independently associated with the risk of subsequent dementia. Methods: We examined associations of baseline NLR with incident dementia risk in the community-based Framingham Heart Study (FHS) longitudinal cohorts. The association between NLR and risk of dementia was evaluated using the cumulative incidence function (CIF) and inverse probability-weighted Cox proportional cause-specific hazards regression models, with adjustment for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, current smoking status, low-density lipoprotein (LDH), high-density lipoprotein (LDL), total cholesterol, triglycerides, and history of cardiovascular disease (CVD). Random forest survival models were used to evaluate the relative predictive value of the model covariates on dementia risk. Results: The final study sample included 1,648 participants with FHS (average age, 69 years; 56% women). During follow-up (median, 5.9 years), we observed 51 cases of incident dementia, of which 41 were AD cases. Results from weighted models suggested that the NLR was independently associated with incident dementia, and it was preceded in predictive value only by age, history of CVD, and blood pressure at baseline. Conclusion: Our study shows that individuals with higher NLR are at a greater risk of subsequent dementia during a 5.9-year follow-up period. Further evaluating the role of neutrophil-mediated inflammation in AD progression may be warranted.
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影响因子：
16.2
作者：
Kim, Jungsu;Basak, Jacob M.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
8.8
作者：
El Amki, Mohamad;Glueck, Chaim;Wegener, Susanne
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作者：
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通讯作者：
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作者：
Doering, Yvonne;Libby, Peter;Soehnlein, Oliver
通讯作者：
Soehnlein, Oliver