Effect of diet on urinary excretion of desmosine and hydroxylysyl pyridinoline.
Effect of diet on urinary excretion of desmosine and hydroxylysyl pyridinoline.
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饮食对锁链素和羟赖氨酰吡啶啉尿排泄的影响。
DOI：
10.1164/ajrccm.149.1.8111578
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发表时间：
1994
影响因子：
24.7
通讯作者：
Franzblau,C
中科院分区：
文献类型：
--
作者：
Stone,PJ;Lucey,EC;Snider,GL;Franzblau,C
为了帮助验证尿锁链素（DES）、异锁链素（IDES）和羟赖氨酰吡啶啉（HP）分别作为宿主弹性蛋白和胶原降解的特异性标志物的用途，进行了关于膳食弹性蛋白和胶原对尿DES、IDES和HP的影响的研究。摄入含有33 g弹性蛋白、500 mg DES和400 mg IDES的小牛项韧带餐，尿DES增加10倍，IDES增加8倍。尿DES值在摄入后10天以上仍保持升高。我们估计约0.3 mg或<0.1%的摄入DES经尿液排泄。由于项韧带不是人类饮食的常见成分，我们还确定了DES、IDES和HP的更典型来源和数量是否会影响尿DES、IDES或HP值。摄入瘦碎牛肉（454 g）。我们的分析表明，这顿饭含有4毫克DES，2毫克IDES和0.9毫克HP。富含肉类的饮食导致尿中肌酐和DES含量分别显著增加16%和34%。当DES、IDES和HP值针对尿肌酸酐含量进行标准化时，饮食对测量值没有影响。基线值在摄入牛肉之前，志愿者的平均值（± SE）为8.3 ± 0.7微克DES/24小时，8.3 ± 0.6微克IDES/24小时和340 ± 48 nmol HP/24小时; 5.7 +/- 0.5微克DES/g肌酸酐，5.6 +/- 0.4微克IDES/g肌酸酐和26.9 +/- 2.2 nmol HP/mmol肌酸酐。（250字处删节）
To help validate the use of urinary desmosine (DES), isodesmosine (IDES), and hydroxylysyl pyridinoline (HP) as specific markers of host elastin and collagen degradation, respectively, a study was carried out on the effect of dietary elastin and collagen on urinary DES, IDES, and HP. Ingestion of a meal of calf ligamentum nuchae containing 33 g elastin, 500 mg DES, and 400 mg IDES produced a 10-fold increase in urinary DES and an 8-fold increase in IDES. The urinary DES values remained elevated for more than 10 days following the ingestion. We estimate that about 0.3 mg, or < 0.1%, of the ingested DES was excreted in the urine. Since ligamentum nuchae is not a usual ingredient of human diets, we also determined whether a more typical source and amount of DES, IDES, and HP might affect urinary DES, IDES, or HP values. Lean ground beef (454 g) was ingested. Our analysis showed that this meal contained 4 mg DES, 2 mg IDES, and 0.9 mg HP. The meat-rich diet caused a significant increase of 16 and 34% in the creatinine and DES content of the urine, respectively. When DES, IDES, and HP values were normalized for the urine creatinine content, diet had no effect on the measured amounts. The baseline values (mean +/- SE) for the volunteers before ingestion of the beef were 8.3 +/- 0.7 micrograms DES/24 h, 8.3 +/- 0.6 micrograms IDES/24 h, and 340 +/- 48 nmol HP/24 h; 5.7 +/- 0.5 micrograms DES/g creatinine, 5.6 +/- 0.4 micrograms IDES/g creatinine, and 26.9 +/- 2.2 nmol HP/mmol creatinine.(ABSTRACT TRUNCATED AT 250 WORDS)
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影响因子：
2.9
作者：
R. Lent;B. Smith;L. Salcedo;B. Faris;C. Franzblau
通讯作者：
C. Franzblau
从新生大鼠主动脉平滑肌细胞培养物中分离出羟赖氨酰吡啶啉，这是一种成熟的胶原交联。
DOI：
10.1016/s0934-8832(11)80034-x
发表时间：
1992
期刊：
Matrix (Stuttgart, Germany)
影响因子：
--
作者：
Stone,PJ;Bryan-Rhadfi,J;Shaw,HA;Franzblau,C
通讯作者：
Franzblau,C
DOI：
10.1164/ajrccm/144.2.284
发表时间：
1991-08
期刊：
The American review of respiratory disease
影响因子：
--
作者：
P. Stone;J. Bryan-Rhadfi;E. Lucey;D. Ciccolella;George Crombie;B. Faris;G. Snider;C. Franzblau
通讯作者：
P. Stone;J. Bryan-Rhadfi;E. Lucey;D. Ciccolella;George Crombie;B. Faris;G. Snider;C. Franzblau
影响因子：
2.9
作者：
EYRE, DR;KOOB, TJ;VANNESS, KP
通讯作者：
VANNESS, KP
尿液分馏以通过放射免疫分析进行锁链素分析
影响因子：
2.2
作者：
B. Starcher;Marti Scott
通讯作者：
Marti Scott