The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats.
The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats.
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抑郁对嗅球切除大鼠诱发和自发疼痛行为的不同影响
DOI：
10.1016/j.neulet.2010.01.075
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发表时间：
2010-03-19
影响因子：
2.5
通讯作者：
Luo F
中科院分区：
文献类型：
--
作者：
Wang W;Qi WJ;Xu Y;Wang JY;Luo F
虽然抑郁和疼痛是常见的合并症，但它们的相互作用尚未完全了解。本研究采用嗅球切除术（OB）大鼠抑郁模型，探讨抑郁对诱发痛行为（热痛）和自发痛行为（福尔马林痛）的影响。情绪行为采用旷场和Morris水迷宫测试。结果表明，与非抑郁动物相比，抑郁大鼠对伤害性热刺激表现出更强的耐受性。与此相反，与对照组大鼠相比，OB大鼠由福尔马林注射诱导的自发伤害性行为显著增强。这些结果表明，抑郁症可以有不同的影响刺激诱发疼痛和自发性疼痛，与减轻在前者，而加重在后者。本研究证实了我们先前的研究结果，即抑郁症可以抑制诱发痛，但促进自发痛，并提供证据，OB抑郁模型是一个可行的模型，用于研究抑郁症和疼痛之间的关系。
Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The current study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception) and spontaneous pain behavior (formalin pain) using an olfactory bulbectomy (OB) rat model of depression. Emotional behaviors were assessed by open field and Morris water maze tests. The results showed that the depressed rats exhibited stronger tolerance to noxious thermal stimulation compared to non-depressed animals. In contrast, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in the OB rats in comparison to control rats. These results demonstrated that depression can have differential effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter. The present study has confirmed our previous findings that depression can inhibit evoked pain but facilitate spontaneous pain, and provides evidence that the OB depression model is a feasible model for studying the relationship between depression and pain.
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影响因子：
3
作者：
BURTON, AK;TILLOTSON, KM;HOLLIS, S
通讯作者：
HOLLIS, S
影响因子：
4.7
作者：
MERSKEY, H
通讯作者：
MERSKEY, H
离皮质输出促进大鼠急性疼痛，但抑制慢性疼痛
影响因子：
7.4
作者：
Wang, Ning;Wang, Jin-Yan;Luo, Fei
通讯作者：
Luo, Fei
影响因子：
5.3
作者：
Andre, J;Zeau, B;Becker, C
通讯作者：
Becker, C
影响因子：
2.5
作者：
Pinto-Ribeiro, F;Almeida, A;Sousa, N
通讯作者：
Sousa, N