Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents.
Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents.
复制标题
DOI：
10.3390/brainsci11020212
复制
发表时间：
2021-02-10
期刊：
影响因子：
3.3
通讯作者：
D'Angiulli A
中科院分区：
文献类型：
--
作者：
Buchanan DM;Bogdanowicz T;Khanna N;Lockman-Dufour G;Robaey P;D'Angiulli A
背景：经颅直流电刺激（tDCS）在成人中是一种安全、可耐受和可接受的技术。然而，关于其在青年中的安全性的证据有限。虽然有限，但有一些重要的经验性文章评估了青年的安全性和耐受性结果。然而，目前尚无儿科安全性研究的综合报告。目的：根据当前文献状态，综合关于儿童tDCS安全性和耐受性的客观证据。方法：我们的检索和报告使用PRISMA指南。我们的方法系统地检查了旨在评估tDCS在健康和非典型青年中的安全性，耐受性和可接受性的调查，这些调查提交给三个数据库，从数据库开始到2019年11月。通过利用神经影像学、生理变化、任务表现的研究，并通过分析报告的和客观的副作用，评价安全性考虑;通过不良事件发生率评价耐受性;通过脱落率评价可接受性。结果：我们报告了156名儿童的203个假会话，864个高达2 mA的活动会话和303个活动小时的刺激。共有4.4%的活动会话是在神经典型的控制，与其他95.6%的临床受试者。结论：尽管目前的证据是零星的和稀缺的，目前审查的文献提供了支持的安全性，耐受性和可接受性，tDCS在青年1-20届20分钟高达2毫安。鼓励未来的儿科tDCS研究。
Background: Transcranial direct current stimulation (tDCS) is a safe, tolerable, and acceptable technique in adults. However, there is limited evidence for its safety in youth. Although limited, there are a handful of important empirical articles that have evaluated safety and tolerability outcomes in youth. However, a synthesis of pediatric safety studies is not currently available. Objective: To synthesize objective evidence regarding the safety and tolerability of pediatric tDCS based on the current state of the literature. Methods: Our search and report used PRISMA guidelines. Our method systematically examined investigations purposefully designed to evaluate the safety, tolerability, and acceptability of tDCS in healthy and atypical youth that were submitted to three databases, from the beginning of the database to November 2019. Safety considerations were evaluated by studies utilizing neuroimaging, physiological changes, performance on tasks, and by analyzing reported and objective side effects; tolerability via rate of adverse events; and acceptability via rate of dropouts. Results: We report on 203 sham sessions, 864 active sessions up to 2 mA, and 303 active hours of stimulation in 156 children. A total of 4.4% of the active sessions were in neurotypical controls, with the other 95.6% in clinical subjects. Conclusion: In spite of the fact that the current evidence is sporadic and scarce, the presently reviewed literature provides support for the safety, tolerability, and acceptability, of tDCS in youth for 1–20 sessions of 20 min up to 2 mA. Future pediatric tDCS research is encouraged.
登录
查看更多内容
影响因子：
3
作者：
Charvet LE;Kasschau M;Datta A;Knotkova H;Stevens MC;Alonzo A;Loo C;Krull KR;Bikson M
通讯作者：
Bikson M
影响因子：
5.5
作者：
Jamil, Asif;Batsikadze, Giorgi;Nitsche, Michael A.
通讯作者：
Nitsche, Michael A.
影响因子：
1.9
作者：
Andrade, Agnes Carvalho;Magnavita, Guilherme Moreira;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
2.5
作者：
Chi, Richard P.;Snyder, Allan W.
通讯作者：
Snyder, Allan W.
影响因子：
3.7
作者：
Ciechanski, Patrick;Kirton, Adam
通讯作者：
Kirton, Adam