In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain.
In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain.
复制标题
在不同插入大脑的插入时，对针力和摩擦应力的体内评估。
DOI：
10.1016/j.jneumeth.2014.08.012
复制
发表时间：
2014-11-30
影响因子：
3
通讯作者：
Sarntinoranont M
中科院分区：
文献类型：
--
作者：
Casanova F;Carney PR;Sarntinoranont M
对流增强输送（CED）将药物直接注入脑组织。需要插入针头，并导致组织损伤，这可能促进沿着针道回流和不正确的靶向。本研究的目的是评价摩擦应力（根据针插入力计算），作为不同插入速度下针插入期间组织接触和损伤的指标。在体内大鼠脑中测量针插入期间的力和表面凹陷。使用针回撤力计算摩擦应力。这些措施进行了比较，从以前的研究轨道损坏。针对不同的插入速度（0.2、2和10 mm/s）评价脑组织和软水凝胶之间的差异。在脑组织中，平均插入力和表面凹陷随着插入速度的增加而增加。沿针-组织界面的平均摩擦应力沿着随着插入速度而减小（0.58 ± 0.27至0.16 ± 0.08 kPa）。各脑区的摩擦应力不同：皮质（0.227 ± 0.27 kPa）、外囊（0.222 ± 0.19 kPa）和CPu（0.383 ± 0.30 kPa）。水凝胶表现出相反的趋势，压痕和摩擦应力与插入速度。以前，已经用组织学方法测量了随着插入速度增加的针损伤。摩擦应力似乎随着组织损伤的增加和组织接触的减少而降低，这为沿着针道进行体内和真实的评价提供了可能性。力产生的摩擦应力随着插入速度的增加而减小，并且在白色物质区域内较小。水凝胶表现出与脑组织相反的趋势。
Convection-enhanced delivery (CED) infuses drugs directly into brain tissue. Needle insertion is required and results in tissue damage which can promote flowback along the needle track and improper targeting. The goal of this study was to evaluate friction stress (calculated from needle insertion force) as a measure of tissue contact and damage during needle insertion for varying insertion speeds. Forces and surface dimpling during needle insertion were measured in rat brain in vivo. Needle retraction forces were used to calculate friction stresses. These measures were compared to track damage from a previous study. Differences between brain tissues and soft hydrogels were evaluated for varying insertion speeds: 0.2, 2, and 10 mm/s. In brain tissue, average insertion force and surface dimpling increased with increasing insertion speed. Average friction stress along the needle-tissue interface decreased with insertion speed (0.58 ± 0.27 to 0.16 ± 0.08 kPa). Friction stress varied between brain regions: cortex (0.227 ± 0.27 kPa), external capsule (0.222 ± 0.19 kPa), and CPu (0.383 ± 0.30 kPa). Hydrogels exhibited opposite trends for dimpling and friction stress with insertion speed. Previously, increasing needle damage with insertion speed has been measured with histological methods. Friction stress appears to decrease with increasing tissue damage and decreasing tissue contact, providing the potential for in vivo and real time evaluation along the needle track. Force-derived friction stress decreased with increasing insertion speed and was smaller within white matter regions. Hydrogels exhibited opposite trends to brain tissue.
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DOI：
10.1109/tra.2003.817044
发表时间：
2003-10-01
期刊：
IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION
影响因子：
--
作者：
DiMaio, SP;Salcudean, SE
通讯作者：
Salcudean, SE
DOI：
10.1109/tbme.2008.2003261
发表时间：
2009-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Sharp AA;Ortega AM;Restrepo D;Curran-Everett D;Gall K
通讯作者：
Gall K
影响因子：
3.7
作者：
Casanova F;Carney PR;Sarntinoranont M
通讯作者：
Sarntinoranont M
DOI：
10.1115/1.4006404
发表时间：
2012-04-01
影响因子：
1.7
作者：
Casanova, Fernando;Carney, Paul R.;Sarntinoranont, Malisa
通讯作者：
Sarntinoranont, Malisa
影响因子：
4.1
作者：
Degen, JW;Walbridge, S;Lonser, RR
通讯作者：
Lonser, RR