Dissociation of BOLD responses to reward prediction errors and reward receipt by a model comparison
Dissociation of BOLD responses to reward prediction errors and reward receipt by a model comparison
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通过模型比较对奖励预测错误和奖励接收的 BOLD 反应进行分离
DOI：
10.1111/j.1460-9568.2012.08125.x
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发表时间：
2012
影响因子：
3.4
通讯作者：
Fliessbach K
中科院分区：
文献类型：
--
作者：
Rohe T;Weber B;Fliessbach K
奖励预期和奖励预测错误的表征是奖励相关学习的基础。是否发生奖励（奖励收据）的表示对于决策非常重要。最近的研究表明，虽然奖励预期和奖励预测错误编码在中脑和腹侧纹状体，奖励接收编码在内侧眶额皮质。为了证实这一功能的专业化，我们分析了从功能磁共振成像研究，其中59名受试者完成了两个简单的金钱奖励范例的数据。由于奖励收入和奖励预测误差相关，因此应用统计模型比较来分离两者的影响。奖励预测误差拟合BOLD反应显着优于奖励接收中脑和腹侧纹状体。相反，奖励接收适合BOLD反应更好地在眶额皮质。与奖励预期相关的激活被发现在眶额皮层。结果证实了功能专业化的行为重要方面的奖励处理中脑边缘多巴胺能系统内。
The representation of reward anticipation and reward prediction errors is the basis for reward‐associated learning. The representation of whether or not a reward occurred (reward receipt) is important for decision making. Recent studies suggest that, while reward anticipation and reward prediction errors are encoded in the midbrain and the ventral striatum, reward receipts are encoded in the medial orbitofrontal cortex. In order to substantiate this functional specialization we analyzed data from an fMRI study in which 59 subjects completed two simple monetary reward paradigms. Because reward receipts and reward prediction errors were correlated, a statistical model comparison was applied separating the effects of the two. Reward prediction error fitted BOLD responses significantly better than reward receipt in the midbrain and the ventral striatum. Conversely, reward receipt fitted BOLD responses better in the orbitofrontal cortex. Activation related to reward anticipation was found in the orbitofrontal cortex. The results confirm a functional specialization of behaviorally important aspects of reward processing within the mesolimbic dopaminergic system.
影响因子：
2.5
作者：
L. Tremblay;W. Schultz
通讯作者：
L. Tremblay;W. Schultz
DOI：
10.1016/b978-012372560-8/50015-2
发表时间：
2007-01-01
期刊：
STATISTICAL PARAMETRIC MAPPING: THE ANALYSIS OF FUNCTIONAL BRAIN IMAGES
影响因子：
--
作者：
Henson, R.
通讯作者：
Henson, R.