Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis.
Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis.
复制标题
抗丝骨体自身抗体阳性与抗丝骨自身抗体阴性 - 原发性胆道肝硬化中门户细胞浸润的比较分析。
DOI：
10.1002/hep.25511
复制
发表时间：
2012-05
期刊：
影响因子：
13.5
通讯作者：
Niu, Junqi
中科院分区：
文献类型：
--
作者：
Jin, Qinglong;Moritoki, Yuki;Lleo, Ana;Tsuneyama, Koichi;Invernizzi, Pietro;Moritoki, Hitoshi;Kikuchi, Kentaro;Lian, Zhe-Xiong;Hirschfield, Gideon M.;Ansari, Aftab A.;Coppel, Ross L.;Gershwin, M. Eric;Niu, Junqi
大量证据支持原发性胆汁性肝硬变(PBC)患者异常的B细胞免疫反应，包括血清抗线粒体抗体(AMAs)的存在。然而，最近来自PBC小鼠模型的报告表明，B细胞也可能提供调节功能，事实上，在这种模型中，B细胞的缺失会导致疾病的恶化。绝大多数前列腺癌患者都有很容易检测到的抗线粒体抗体，但少数患者(5%)即使采用重组诊断技术也是AMA阴性(AMA−)。这一问题促使我们研究AMA阳性(AMA+)和AMA−患者门脉周围B细胞浸润的性质，因为它们表现出难以区分的临床特征。重要的是发现门脉周围胆管损害的程度在AMA+PBC组明显轻于AMA−PBC组。AMA型−患者肝门区胆管内CD5+细胞明显增多，B细胞浸润程度在胆管损伤早期加重。胆管侵袭区阳性汇管区的出现频率和CD5+、CD20+细胞浸润量与胆管上皮损伤的最初证据有关，但在胆管减少期除CD5+细胞外，CD5+细胞仍持续存在，且以CD20+细胞为主。综上所述，我们的数据提示B细胞自身免疫在调节PBC的门静脉破坏特征中可能起着作用。
Substantial evidence supports dysregulated B cell immune responses in patients with primary biliary cirrhosis (PBC), including the presence of serum anti-mitochondrial antibodies (AMAs). However, recent reports from murine models of PBC suggest that B cells may also provide regulatory function and indeed the absence of B cells in such models leads to exacerbation of disease. The vast majority of patients with PBC have readily detectable antimitochondrial antibodies, but a minority (<5%), are AMA negative (AMA−) even with recombinant diagnostic technology. This issue prompted us to examine the nature of B cell infiltrates surrounding the portal areas in AMA positive (AMA+) and AMA− patients since they display indistinguishable clinical features. Of importance was the finding that the degree of bile duct damage around the portal areas was significantly milder in AMA+ PBC than those seen in AMA− PBC patients. The portal areas from AMA− patients had a significant increase of CD5+ cells infiltrating the ductal regions and the levels of B cell infiltrates were worse in the early phase of bile duct damage. The frequency of positive portal areas and the magnitude of CD5+ and CD20+ cellular infiltrates within areas of ductal invasion is associated with the first evidence of damage of biliary duct epithelia, but becomes reduced in the ductopenia stage, with the exception of CD5+ cells which remain sustained and predominate over CD20+ cells. In conclusion, our data suggest a putative role of B cell autoimmunity in regulating the portal destruction characteristic of PBC.
登录
查看更多内容
影响因子：
13.5
作者：
Lleo, Ana;Selmi, Carlo;Invernizzi, Pietro;Podda, Mauro;Coppel, Ross L.;Maclay, Ian R.;Gores, Gregory J.;Ansari, Aftab A.;de Water, Judy Van;Gershwin, M. Eric
通讯作者：
Gershwin, M. Eric
影响因子：
15.9
作者：
Matsushita, Takashi;Yanaba, Koichi;Tedder, Thomas F.
通讯作者：
Tedder, Thomas F.
影响因子：
25.7
作者：
Curry, MP;Golden-Mason, L;O'Farrelly, C
通讯作者：
O'Farrelly, C
影响因子：
9.3
作者：
Daehnrich, Cornelia;Pares, Albert;Komorowski, Lars
通讯作者：
Komorowski, Lars
DOI：
10.1016/j.bbrc.2009.09.012
发表时间：
2009-11-20
影响因子：
3.1
作者：
Mizuochi, Toshiaki;Ito, Masahiko;Yamaguchi, Kazunari
通讯作者：
Yamaguchi, Kazunari