Intravascular granuloma induced by intravenous inoculation ofCryptococcus neoformans
Intravascular granuloma induced by intravenous inoculation ofCryptococcus neoformans
复制标题
静脉接种新生隐球菌致血管内肉芽肿
DOI：
10.1007/bf02373022
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发表时间：
2006
期刊：
影响因子：
5.5
通讯作者：
Makoto Ito
中科院分区：
文献类型：
--
作者：
Hideyuki Yamaoka;N. Sakaguchi;K. Sano;Makoto Ito
在啮齿类动物中，静脉注射活的新型隐球菌 (C.) 细胞经常会导致血管内隐球菌肉芽肿附着在各种器官（包括肺、肝和脾）的大到中型静脉的内壁上。为了阐明肉芽肿改变的发病机制，通过电子显微镜过氧化物酶（PO）细胞化学观察组成血管内肉芽肿的细胞。根据内源性过氧化物酶活性模式，肉芽肿构成细胞可分为以下四种类型：渗出型巨噬细胞（Mφ，I型）、PO阴性Mφ（II型）、驻留Mφ（III型）和其他炎症细胞（IV型）。肺静脉肉芽肿中，I型为39.0%，II型为57.9%，III型为0%，IV型为3.1%。相比之下，在肺间质肉芽肿中，III 型 Mφs（可能源自肺泡 Mφs）在肉芽肿形成中发挥了重要作用。这可能表明血管内肉芽肿几乎由单核细胞来源的巨噬细胞而不是肺泡巨噬细胞组成。免疫电镜检测肺静脉内皮细胞ICAM-1的表达。响应于 C 的静脉内攻击，内皮细胞表面的免疫金标记指数显着增强。新型隐球菌。血管内肉芽肿表明单核细胞发育成肉芽肿组成巨噬细胞，甚至在外周血中也抑制隐球菌活性，从而辅助内皮功能。
In rodents an intravenous administration of viableCryptococcus (C.) neoformans cells frequently resulted in attachment of intravascular cryptococcal granulomas to inner walls of the large to medium-sized veins of various organs, including the lungs, liver and spleen. In order to elucidate the pathogenesis of granulomatous changes, the cells composing the intravascular granulomas were observed by electron microscopic peroxidase (PO) cytochemistry. The granuloma composing cells could be divided into the following four types according to the pattern of endogenous peroxidase activity: exudate macrophage (Mφ, type I), PO-negative Mφ (type II), resident Mφ (type III) and other inflammatory cells (type IV). In the intravenous granulomas of the lung, the percentages of composed cells were 39.0% for type I, 57.9% for type II, 0% for type III and 3.1% for type IV. By contrast, in the interstitial granulomas in the lung, type III Mφs, possibly derived from alveolar Mφs, played a significant role in granuloma formation. This may indicate that the intravascular granuloma is almost composed of macrophages derived from monocytes rather than alveolar macrophages. The expression of ICAM-1 on endothelia of the pulmonary veins was examined by immunoelectron microscopy. An immunogold labeling index was significantly augmented on the surface of endothelia in response to intravenous challenge ofC. neoformans. The intravascular granuloma demonstrates that the monocytes develop into the granuloma-composing macrophages and suppress the cryptococcal activities even hi the peripheral blood resulting in an assistance of endothelial functions.
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影响因子：
15.9
作者：
LEVITZ, SM;TABUNI, A
通讯作者：
TABUNI, A
影响因子：
4.4
作者：
Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer
通讯作者：
Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer
人肺泡巨噬细胞对新型隐球菌的生长抑制。
DOI：
10.1164/ajrccm/136.5.1242
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Weinberg,PB;Becker,S;Granger,DL;Koren,HS
通讯作者：
Koren,HS
大鼠肺泡巨噬细胞杀死新型隐球菌。
DOI：
--
发表时间：
1989
期刊：
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology
影响因子：
--
作者：
Bolanos,B;Mitchell,TG
通讯作者：
Mitchell,TG