The Effects of Hypocapnia on Brain Tissue Pulsations.
The Effects of Hypocapnia on Brain Tissue Pulsations.
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DOI：
10.3390/brainsci10090614
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发表时间：
2020-09-06
期刊：
影响因子：
3.3
通讯作者：
Chung EML
中科院分区：
文献类型：
--
作者：
Alharbi M;Turner P;Ince J;Oura M;Ebirim KU;Almudayni A;Lecchini-Visintini A;Minhas JS;Chung EML
已知低碳酸血症会影响急性中风患者，并在控制脑自动调节中起关键作用。然而，低碳酸血症对脑组织搏动（BTP）的影响相对未被探索。由于BTP被假设是由对脉动动脉血流入的脑血管阻力引起的，因此还假设由低碳酸血症介导的脑自动调节变化将改变BTP振幅。这项健康志愿者研究报告了使用经颅组织多普勒（TCTD）获得的BTP测量值。30名参与者进行过度通气以诱导轻度低碳酸血症。然后分析BTP振幅、EtCO2、血压和心率，以探讨低碳酸血症对BTP振幅的影响。在从低碳酸血症中恢复的过程中，观察到BTP振幅的显著变化，但在过度通气操作本身过程中没有观察到。然而，心率和脉压的显著增加以及平均动脉压的降低也被观察到伴随着低碳酸血症，这可能混淆了我们的发现。虽然需要进一步的调查，但这项研究的结果为更好地了解二氧化碳水平对BTP的影响提供了一个起点。需要在这一领域进行进一步的研究，以确定BTP的主要生理驱动因素，并量化它们与脑血流动力学其他方面的相互作用。
Hypocapnia is known to affect patients with acute stroke and plays a key role in governing cerebral autoregulation. However, the impact of hypocapnia on brain tissue pulsations (BTPs) is relatively unexplored. As BTPs are hypothesised to result from cerebrovascular resistance to the inflow of pulsatile arterial blood, it has also been hypothesised that cerebral autoregulation changes mediated by hypocapnia will alter BTP amplitude. This healthy volunteer study reports measurements of BTPs obtained using transcranial tissue Doppler (TCTD). Thirty participants underwent hyperventilation to induce mild hypocapnia. BTP amplitude, EtCO2, blood pressure, and heart rate were then analysed to explore the impact of hypocapnia on BTP amplitude. Significant changes in BTP amplitude were noted during recovery from hypocapnia, but not during the hyperventilation manoeuvre itself. However, a significant increase in heart rate and pulse pressure and decrease in mean arterial pressure were also observed to accompany hypocapnia, which may have confounded our findings. Whilst further investigation is required, the results of this study provide a starting point for better understanding of the effects of carbon dioxide levels on BTPs. Further research in this area is needed to identify the major physiological drivers of BTPs and quantify their interactions with other aspects of cerebral haemodynamics.
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影响因子：
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