Cellular reservoirs of HIV-1 and their role in viral persistence.
Cellular reservoirs of HIV-1 and their role in viral persistence.
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HIV-1 的细胞储存库及其在病毒持久性中的作用。
DOI：
10.2174/157016208785861195
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发表时间：
2008-09
影响因子：
1
通讯作者：
Wigdahl B
中科院分区：
文献类型：
--
作者：
Alexaki A;Liu Y;Wigdahl B
人类免疫缺陷病毒1型（HIV-1）根除的一个主要障碍是病毒在其感染的细胞亚群中保持潜伏的能力。潜伏感染的细胞可以逃避病毒免疫反应，并持续很长一段时间，尽管存在成功的高效抗逆转录病毒疗法（HAART）。给予适当的刺激，潜伏感染的细胞可以重新激活并开始产生感染性病毒体。这些细胞群体对HIV-1的易感性、它们的寿命、它们的增殖能力以及它们在细胞生理学和/或免疫学控制改变之后周期性地产生感染性病毒的能力是决定这些细胞对病毒持久性的贡献的关键问题。记忆性CD 4 + T细胞由于其寿命长（可能为数年）以及在遇到其同源抗原或其他刺激时重新激活的能力，被认为是维持潜伏HIV-1前病毒DNA的关键储存库。起源于骨髓（BM）的单核细胞-巨噬细胞谱系的细胞在HIV-1持久性中特别重要，因为它们能够穿过血脑屏障（BBB）并在免疫豁免的中枢神经系统（CNS）中传播HIV-1感染。造血祖细胞（HPCs）也是一个潜在的HIV-1储库，因为几项研究表明，携带前病毒DNA的CD 34 + HPCs可以在HIV-1感染患者的亚群中体内发现。HPC增殖和潜在产生单核细胞-巨噬细胞系感染细胞克隆群体的能力可能在HIV-1传播中至关重要。这些和其他细胞群体在HIV-1的持久性，以及可能的战略，以消除潜伏感染的细胞的贡献在这篇评论中严格审查。
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the appropriate stimulus, latently infected cells can reactivate and start producing infectious virions. The susceptibility of these cell populations to HIV-1, their life span, their proliferative capacity, and their ability to periodically produce infectious virus subsequent to alterations in cellular physiology and/or immunologic controls are critical issues which determine the contribution of these cells to viral persistence. Memory CD4+ T cells due to the long life span, which may be several years, and their ability to reactivate upon encounter with their cognate antigen or other stimulation, are considered a critical reservoir for maintenance of latent HIV-1 proviral DNA. Cells of the monocyte-macrophage lineage, which originate in the bone marrow (BM), are of particular importance in HIV-1 persistence due to their ability to cross the blood-brain barrier (BBB) and spread HIV-1 infection in the immunoprivileged central nervous system (CNS). Hematopoietic progenitor cells (HPCs) are also a potential HIV-1 reservoir, as several studies have shown that CD34+ HPCs carrying proviral DNA can be found in vivo in a subpopulation of HIV-1-infected patients. The ability of HPCs to proliferate and potentially generate clonal populations of infected cells of the monocyte-macrophage lineage may be crucial in HIV-1 dissemination. The contribution of these and other cell populations in HIV-1 persistence, as well as the possible strategies to eliminate latently infected cells are critically examined in this review.
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影响因子：
5.4
作者：
Canki, M;Thai, JNF;Volsky, DJ
通讯作者：
Volsky, DJ
DOI：
10.1073/pnas.95.15.8869
发表时间：
1998-07-21
影响因子：
11.1
作者：
Chun, TW;Engel, D;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
3.8
作者：
Bagasra, O;Lavi, E;Pomerantz, RJ
通讯作者：
Pomerantz, RJ
影响因子：
5.4
作者：
Burleigh, L;Lozach, PY;Amara, A
通讯作者：
Amara, A
使用细胞因子的组合在潜在感染的CD4+ T细胞中诱导HIV-1复制。
DOI：
10.1084/jem.188.1.83
发表时间：
1998-07-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
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