Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.
Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.
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DOI：
10.3390/ijerph17218056
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发表时间：
2020-11-01
影响因子：
--
通讯作者：
North KE
中科院分区：
文献类型：
--
作者：
Divaris K;Slade GD;Ferreira Zandona AG;Preisser JS;Ginnis J;Simancas-Pallares MA;Agler CS;Shrestha P;Karhade DS;Ribeiro AA;Cho H;Gu Y;Meyer BD;Joshi AR;Azcarate-Peril MA;Basta PV;Wu D;North KE
幼儿龋齿(ECC)是一种侵袭性的龋齿形式，发生在生命的头五年。尽管它的流行和后果，但在预防方面取得的进展很少，对个人易感性或基因组风险因素的了解更少。ECC的全基因组关联研究(“ZOE 2.0”)是一项以社区为基础的、多种族的、横断面的遗传流行病学研究，旨在解决这一知识差距。本文描述了这项研究的设计、队列的人口统计学特征、数据域和关键的口腔健康结果。2016至2019年间，这项研究招募了8059名在美国北卡罗来纳州公立学前班就读的3-5岁儿童。参与者居住在该州100个县中的86个县，种族/少数民族占多数--例如，48%(n=3872)是非洲裔美国人，22%是白人，20%(n=1611)是西班牙裔/拉丁裔。79%(n=6404)的参与者接受了临床牙科检查，得出了ECC结果指标-ECC(以既定的龋损阈值定义)患病率为54%，因龋齿而导致的平均腐烂、缺失和充填表面的数量为8个。几乎所有接受检查的儿童(98%)都提供了足够的唾液DNA用于基因分型。该队列以社区为基础的性质和丰富的数据为解决儿童早期的重要临床、流行病学和生物学问题提供了极好的机会。
Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (n = 3872) were African American, 22% white, and 20% (n = 1611) were Hispanic/Latino. Seventy-nine percent (n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.
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影响因子：
5.5
作者：
Khoury MJ;Iademarco MF;Riley WT
通讯作者：
Riley WT
影响因子：
--
作者：
Divaris, K
通讯作者：
Divaris, K
DOI：
10.1007/978-1-4939-9012-2_38
发表时间：
2019-01-01
期刊：
ODONTOGENESIS
影响因子：
--
作者：
Agler, Cary S.;Shungin, Dmitry;Divaris, Kimon
通讯作者：
Divaris, Kimon
影响因子：
1.8
作者：
Born, Catherine D.;Jackson, Tate H.;Divaris, Kimon
通讯作者：
Divaris, Kimon
影响因子：
7.6
作者：
Casamassimo, P. S.;Lee, J. Y.;Divaris, K.
通讯作者：
Divaris, K.