The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.
复制标题
Kynurenine途径在青春期重度抑郁症中的自杀性中的作用。
DOI：
10.1016/j.psychres.2015.03.031
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发表时间：
2015-06-30
影响因子：
11.3
通讯作者：
Gabbay, Vilma
中科院分区：
文献类型：
--
作者：
Bradley, Kailyn A. L.;Case, Julia Ac.;Khan, Omar;Ricart, Thomas;Hanna, Amira;Alonso, Carmen M.;Gabbay, Vilma
神经免疫学犬尿氨酸通路（KP）与成人和青少年的重度抑郁症（MDD）有关，最近与成人的自杀倾向有关。KP由吲哚胺2，3-双加氧酶（IDO）启动，该酶将色氨酸（TRP）降解为犬尿氨酸（KYN），从而形成神经毒素。在这里，我们检查了20自杀抑郁症患者的KP-由过去的自杀者和那些谁表示积极的自杀意图-30非自杀抑郁青年，和22名健康对照（HC）。评估TRP、KYN、3-羟基邻氨基苯甲酸和KYN/TRP（IDO指数）的血浆水平。与非自杀抑郁青少年和HC相比，自杀青少年TRP降低，KYN/TRP升高。当排除接受药物治疗的参与者时，结果变得更加明显，其中KYN/TRP和自杀倾向之间也存在显著的正相关性。最后，虽然有自杀企图史的抑郁青少年与急性自杀青少年在疾病严重程度、快感缺乏和自杀倾向方面不同，但两组在KP指标上没有差异。我们的研究结果表明，KP在抑郁症青少年自杀倾向中可能发挥特定作用，同时说明了具有自杀企图史的抑郁症青少年与急性自杀青年相似的临床现象，并且自杀完成的风险增加。
The neuroimmunological kynurenine pathway (KP) has been implicated in major depressive disorder (MDD) in adults and adolescents, most recently in suicidality in adults. The KP is initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (TRP) into kynurenine (KYN) en route to neurotoxins. Here, we examined the KP in 20 suicidal depressed adolescents—composed of past attempters and those who expressed active suicidal intent—30 non-suicidal depressed youth, and 22 healthy controls (HC). Plasma levels of TRP, KYN, 3-hydroxyanthranilic acid, and KYN/TRP (index of IDO) were assessed. Suicidal adolescents showed decreased TRP and elevated KYN/TRP compared to both non-suicidal depressed adolescents and HC. Findings became more significantly pronounced when excluding medicated participants, wherein there was also a significant positive correlation between KYN/TRP and suicidality. Finally, although depressed adolescents with a history of suicide attempt differed from acutely suicidal adolescents with respect to disease severity, anhedonia, and suicidality, the groups did not differ in KP measures. Our findings suggest a possible specific role of the KP in suicidality in depressed adolescents, while illustrating the clinical phenomenon that depressed adolescents with a history of suicide attempt are similar to acutely suicidal youth and are at increased risk for completion of suicide.
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DOI：
10.1038/npp.2012.248
发表时间：
2013-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.3
作者：
Gabbay, Vilma;Ely, Benjamin A.;Liebes, Leonard
通讯作者：
Liebes, Leonard
影响因子：
5.9
作者：
Brown, GK;Beck, AT;Grisham, JR
通讯作者：
Grisham, JR
影响因子：
7.6
作者：
Mann, JJ;Malone, KM;Stanley, M
通讯作者：
Stanley, M
DOI：
10.1097/00004583-199305000-00006
发表时间：
1993-05-01
影响因子：
13.3
作者：
BRENT, DA;PERPER, JA;BAUGHER, M
通讯作者：
BAUGHER, M