HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population.
HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population.
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DOI：
10.1186/1746-1596-8-76
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发表时间：
2013-05-09
影响因子：
2.6
通讯作者：
Lu N
中科院分区：
文献类型：
--
作者：
Shan L;Ying J;Lu N
根据不同的免疫组织化学评分标准和患者队列，her2在胃癌（GC）和胃食管交界处（GEJ）腺癌中的阳性率已被广泛报道。最近建立并推荐了胃癌和胃癌的标准化评分标准。在本研究中，我们检测了HER2的表达频率以及HER2表达与中国胃癌和胃癌患者临床病理特征的关系。采用免疫组化（IHC）方法回顾性分析1463例患者的HER2过表达，其中包括929例原发性胃癌和534例原发性GEJ腺癌。采用荧光原位杂交（FISH）技术对308例胃癌和GEJ腺癌患者进行HER2基因扩增检测。在9.8%的肿瘤中检测到HER2过表达（3+），在GEJ癌、肠型、分化良好型和中分化型中更常见（P值分别为0.003、0.000和0.000）。14.4%的病例检测到HER2模棱两可（2+）。FISH分析的308例中，39例（40例中占97.5%）IHC 3+， 11例（38例中占28.9%）IHC 2+， 3例（230例中占1.3%）IHC 1+/0出现HER2基因扩增。IHC与FISH的一致性较高（98.5%）。大约10%的中国原发性胃癌和GEJ腺癌患者在免疫组化上呈her2阳性。HER2过表达与GEJ位点、肠癌亚型、高分化或中分化癌相关。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1935951199941072。
With varied immunohistochemistry scoring criteria and patient cohorts, HER2-positivity rates in gastric cancer (GC) and gastroesophageal junction (GEJ) adenocarcinoma have been reported with a wide range. Recently standardized scoring criteria for GC and GEJ cancer has been established and recommended. In this study, the frequency of HER2 expression and the relationship between HER2 expression and clinicopathological features were examined in a large cohort of Chinese GC and GEJ cancer patients. A total of 1463 patients, including 929 primary GCs and 534 primary GEJ adenocarcinomas, was retrospectively analyzed for HER2 overexpression by immunohistochemistry (IHC). Fluorescence in situ hybridization (FISH) analysis was used in 308 GCs and GEJ adenocarcinoma cases to assess HER2 gene amplification. HER2 overexpression (3+) was detected in 9.8% of carcinomas and more frequently observed in GEJ cancer cases, in the intestinal type, and in the well or moderately differentiated type (P=0.003, 0.000, and 0.000, respectively). HER2 equivocal (2+) was detected in 14.4% of cases. As for the 308 cases analyzed by FISH, 39 (of 40, 97.5%) IHC 3+ cases, 11 (of 38, 28.9%) IHC 2+ cases, and 3 (of 230, 1.3%) IHC 1+/0 cases showed HER2 gene amplification. A high concordance rate (98.5%) between IHC and FISH was demonstrated. Approximately 10% of Chinese patients with primary GC and GEJ adenocarcinoma were HER2-positive on IHC. HER2 overexpression was associated with GEJ site, intestinal cancer subtype, and well or moderately differentiated carcinomas. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1935951199941072.
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影响因子：
3.4
作者：
Gravalos, Cristina;Gomez-Martin, Carlos;Jimeno, Antonio
通讯作者：
Jimeno, Antonio
影响因子：
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作者：
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影响因子：
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作者：
Barros-Silva, J. D.;Leitao, D.;Afonso, L.;Vieira, J.;Dinis-Ribeiro, M.;Fragoso, M.;Bento, M. J.;Santos, L.;Ferreira, P.;Rego, S.;Brandao, C.;Carneiro, F.;Lopes, C.;Schmitt, F.;Teixeira, M. R.
通讯作者：
Teixeira, M. R.
影响因子：
0.3
作者：
Weissinger, Florian;Reymond, Marc;Krueger, Martin
通讯作者：
Krueger, Martin
DOI：
10.3233/clo-2009-0497
发表时间：
2010
期刊：
Cellular oncology : the official journal of the International Society for Cellular Oncology
影响因子：
--
作者：
Grabsch H;Sivakumar S;Gray S;Gabbert HE;Müller W
通讯作者：
Müller W