Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients.
Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients.
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DOI：
10.1038/sj.bjc.6604885
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发表时间：
2009-02-10
影响因子：
8.8
通讯作者：
Teixeira, M. R.
中科院分区：
文献类型：
--
作者：
Barros-Silva, J. D.;Leitao, D.;Afonso, L.;Vieira, J.;Dinis-Ribeiro, M.;Fragoso, M.;Bento, M. J.;Santos, L.;Ferreira, P.;Rego, S.;Brandao, C.;Carneiro, F.;Lopes, C.;Schmitt, F.;Teixeira, M. R.
ERBB2扩增/过表达在胃癌中的临床意义尚不清楚。在本研究中，我们用免疫组织化学(IHC)和荧光原位杂交(FISH)方法检测了463例胃癌组织中ERBB2的表达情况，并与病理组织学特征和疾病特异性生存期进行了比较。43例(9.3%)和38例(8.2%)⩾B_2过度表达(2+和3+)，扩增(ERB_2/CEP17)。19例IHC/FISH评分均为0(FISH均为阴性)，25例为3+(FISH均为阳性)，均具有良好的IHC/FISH相关性。每6例癌中有1例FISH阳性，18例2+癌中有12例阳性。ERBB2基因扩增与肠型胃癌相关(P=0.007)，与扩张型生长相关(P=0.021)。ERBB2扩增在两例混合癌的两个组织成分中都被检测到，表明共同的克隆性起源。在扩张型胃癌患者中，ERBB2基因扩增与患者的生存不良显著相关(P=0.011)。我们的结论是，ERBB2状态在部分胃癌患者中可能具有临床意义，并且有必要进一步研究以评估存在ERBB2扩增/过表达的胃癌患者是否可以受益于针对该表面受体的治疗。
The clinical significance of ERBB2 amplification/overexpression in gastric cancer remains unclear. In this study, we evaluated the ERBB2 status in 463 gastric carcinomas using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and compared the findings with histopathological characteristics and with disease-specific survival. ERBB2 overexpression (2+ and 3+) and amplification (ratio ERBB2/CEP17⩾2) were found in 43 (9.3%) and 38 (8.2%) gastric carcinomas, respectively. Perfect IHC/FISH correlation was found for the 19 cases scored as 0 (all negative by FISH), and also for the 25 cases scored as 3+ (all positive by FISH). One out of six carcinomas scored as 1+ and 12 out of 18 carcinomas scored as 2+ were positive by FISH. ERBB2 amplification was associated with gastric carcinomas of intestinal type (P=0.007) and with an expansive growth pattern (P=0.021). ERBB2 amplification was detected in both histological components of two mixed carcinomas, indicating a common clonal origin. A statistically significant association was found between ERBB2 amplification and worse survival in patients with expansive gastric carcinomas (P=0.011). We conclude that ERBB2 status may have clinical significance in subsets of gastric cancer patients, and that further studies are warranted to evaluate whether patients whose gastric carcinomas present ERBB2 amplification/overexpression may benefit from therapy targeting this surface receptor.
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