Defining the factors that affect solute permeation of gap junction channels.
Defining the factors that affect solute permeation of gap junction channels.
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定义影响间隙连接通道溶质渗透的因素。
DOI：
10.1016/j.bbamem.2017.07.002
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Brink,PeterR
中科院分区：
文献类型：
--
作者：
Valiunas,Virginijus;Cohen,IraS;Brink,PeterR
本文综述了同型缝隙连接通道的孔和前庭的生物物理性质和结构，因为它们与通道的渗透性和选择性有关。缝隙连接通道的独特之处在于其连接两个相邻细胞的细胞质的唯一作用。一般来说，这些通道被认为是选择性差，具有接近统一的开放概率，并表现出从毫秒到秒的平均开放时间。这些性质表明，这种通道可以作为细胞间的传递途径，传递比单价离子大得多的溶质。我们已经采取了定量数据，从已发表的作品有关单位电导，离子通量，和渗透性的同型连接蛋白43（Cx43），Cx40，Cx 26，Cx 50，和Cx 37，并进行了比较分析的电导和/或离子/溶质通量与扩散系数。单价阳离子通量的分析描绘的孔相当于一个水的空间，其中氢键和弱相互作用与结合位点占主导地位。对于较大的溶质，尺寸、形状和电荷也是决定渗透速率的重要因素。这篇文章是特刊的一部分，题为：间隙连接蛋白质编辑让克劳德埃尔韦。
This review focuses on the biophysical properties and structure of the pore and vestibule of homotypic gap junction channels as they relate to channel permeability and selectivity. Gap junction channels are unique in their sole role to connect the cytoplasm of two adjacent cells. In general, these channels are considered to be poorly selective, possess open probabilities approximating unity, and exhibit mean open times ranging from milliseconds to seconds. These properties suggest that such channels can function as delivery pathways from cell to cell for solutes that are significantly larger than monovalent ions. We have taken quantitative data from published works concerning unitary conductance, ion flux, and permeability for homotypic connexin 43 (Cx43), Cx40, Cx26, Cx50, and Cx37, and performed a comparative analysis of conductance and/or ion/solute flux versus diffusion coefficient. The analysis of monovalent cation flux portrays the pore as equivalent to an aqueous space where hydrogen bonding and weak interactions with binding sites dominate. For larger solutes, size, shape and charge are also significant components in determining the permeation rate. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.
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在新生大鼠心脏细胞中检查 connexin43 间隙连接通道的电导和选择性通透性。
影响因子：
20.1
作者：
V. Valiunas;F. Bukauskas;R. Weingart
通讯作者：
R. Weingart
影响因子：
3.4
作者：
Banach, K;Ramanan, SV;Brink, PR
通讯作者：
Brink, PR
影响因子：
3.4
作者：
Heyman, Nathanael S.;Burt, Janis M.
通讯作者：
Burt, Janis M.
影响因子：
56.9
作者：
Unger, VM;Kumar, NM;Yeager, M
通讯作者：
Yeager, M
测量心脏间隙连接处的单通道电流。
DOI：
10.1126/science.2426781
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Veenstra,RD;DeHaan,RL
通讯作者：
DeHaan,RL