Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis.
Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis.
复制标题
终生限制饮食蛋白质会加速骨骼肌的损失，并通过破坏蛋白质平衡和线粒体平衡来减小肌肉纤维的大小。
DOI：
10.1016/j.redox.2023.102980
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发表时间：
2024-02
期刊：
影响因子：
11.4
通讯作者：
Vasilaki, Aphrodite
中科院分区：
文献类型：
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作者：
Ersoy, Ufuk;Kanakis, Ioannis;Alameddine, Moussira;Pedraza-Vazquez, Gibran;Ozanne, Susan E.;Peffers, Mandy Jayne;Jackson, Malcolm J.;Goljanek-Whysall, Katarzyna;Vasilaki, Aphrodite
关键词：
早期生活环境显著影响与年龄相关的骨骼肌疾病的发展。然而，长期影响哺乳蛋白限制骨骼肌仍然很难确定。我们的研究表明，哺乳期喂养低蛋白饮食的母鼠喂养的雄性小鼠表现出骨骼肌生长受限。这与核糖体、线粒体和骨骼肌发育相关基因的表达水平失调有关。我们报道了终身蛋白质限制加速IIa型肌纤维的损失，并通过损害18个月龄时的线粒体稳态和蛋白质稳态来减少肌纤维的大小。然而，在哺乳期蛋白质限制后喂养正常蛋白质饮食可以防止后期纤维损失加速和纤维尺寸减小。这些发现为哺乳蛋白限制阻碍骨骼肌生长的机制提供了新的见解，并包括终身饮食蛋白限制加速晚年骨骼肌损失的证据。终身蛋白质限制会加速肌肉纤维损失并减少纤维大小。终身蛋白质限制破坏骨骼肌线粒体内稳态。终身蛋白质限制可能会损害小鼠骨骼肌的蛋白质稳态。限制哺乳蛋白的有害影响是可以纠正的。不理想的早期生活的不利影响取决于它的时间。
The early life environment significantly affects the development of age-related skeletal muscle disorders. However, the long-term effects of lactational protein restriction on skeletal muscle are still poorly defined. Our study revealed that male mice nursed by dams fed a low-protein diet during lactation exhibited skeletal muscle growth restriction. This was associated with a dysregulation in the expression levels of genes related to the ribosome, mitochondria and skeletal muscle development. We reported that lifelong protein restriction accelerated loss of type-IIa muscle fibres and reduced muscle fibre size by impairing mitochondrial homeostasis and proteostasis at 18 months of age. However, feeding a normal-protein diet following lactational protein restriction prevented accelerated fibre loss and fibre size reduction in later life. These findings provide novel insight into the mechanisms by which lactational protein restriction hinders skeletal muscle growth and includes evidence that lifelong dietary protein restriction accelerated skeletal muscle loss in later life. Lifelong protein restriction accelerates muscle fibre loss and reduces fibre size. Lifelong protein restriction disrupts mitochondrial homeostasis in skeletal muscle. Lifelong protein restriction may impair proteostasis in skeletal muscle in mice. The detrimental effects of lactational protein restriction can be corrected. The adverse effects of suboptimal early life depend on its timing.
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影响因子：
5.6
作者：
通讯作者：
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影响因子：
64.5
作者：
Chen H;Vermulst M;Wang YE;Chomyn A;Prolla TA;McCaffery JM;Chan DC
通讯作者：
Chan DC
DOI：
10.1152/ajpendo.00439.2007
发表时间：
2008-09-01
影响因子：
5.1
作者：
Garcia-Souza, Erica Patricia;da Silva, Simone Vargas;Barja-Fidalgo, Christina
通讯作者：
Barja-Fidalgo, Christina
影响因子：
6
作者：
Kanakis I;Alameddine M;Folkes L;Moxon S;Myrtziou I;Ozanne SE;Peffers MJ;Goljanek-Whysall K;Vasilaki A
通讯作者：
Vasilaki A
影响因子：
3.9
作者：
通讯作者：
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