Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviors.
Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviors.
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DOI：
10.1371/journal.pone.0076901
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xia Z
中科院分区：
文献类型：
--
作者：
Zou J;Storm DR;Xia Z
ERK5 MAP 激酶在发育中的神经系统中高度表达，但在成人大脑的大部分区域中不存在。它与调节主嗅球的发育和气味辨别有关。然而，它是否在基于信息素的行为中发挥重要作用尚未确定。在这里，我们报告，在小鼠神经干细胞中条件性删除编码 ERK5 的 Mapk7 基因会损害几种信息素介导的行为，包括雄性小鼠的攻击性和交配行为。这些缺陷不是由睾酮水平降低、身体不动、恐惧或焦虑加剧或抑郁引起的。使用小鼠尿液作为含有天然信息素的溶液，我们提供的证据表明，行为障碍与密切相关信息素的检测缺陷以及它们对与性和生殖活动相关的信息素的先天偏好的变化有关。我们得出的结论是，发育过程中 ERK5 的表达对于成年小鼠的信息素反应和相关动物行为至关重要。
ERK5 MAP kinase is highly expressed in the developing nervous system but absent in most regions of the adult brain. It has been implicated in regulating the development of the main olfactory bulb and in odor discrimination. However, whether it plays an essential role in pheromone-based behavior has not been established. Here we report that conditional deletion of the Mapk7 gene which encodes ERK5 in mice in neural stem cells impairs several pheromone-mediated behaviors including aggression and mating in male mice. These deficits were not caused by a reduction in the level of testosterone, by physical immobility, by heightened fear or anxiety, or by depression. Using mouse urine as a natural pheromone-containing solution, we provide evidence that the behavior impairment was associated with defects in the detection of closely related pheromones as well as with changes in their innate preference for pheromones related to sexual and reproductive activities. We conclude that expression of ERK5 during development is critical for pheromone response and associated animal behavior in adult mice.
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