The Role of Ubiquitination and SUMOylation in Telomere Biology.
The Role of Ubiquitination and SUMOylation in Telomere Biology.
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DOI：
10.21775/cimb.035.085
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发表时间：
2020
影响因子：
3.1
通讯作者：
Gupta A
中科院分区：
文献类型：
--
作者：
Zalzman M;Meltzer WA;Portney BA;Brown RA;Gupta A
端粒是一种独特的DNA重复结构，由染色体末端的蛋白质覆盖，保护基因组的编码区，并起生物钟的作用。它们需要严格调节覆盖和保护其结构的因子，因为它们随着每次细胞分裂而缩短，以限制细胞不受控制地复制的能力。此外，它们保护染色体末端免受DNA损伤反应，从而防止基因组不稳定性。端粒功能障碍可导致染色体异常和癌症。因此，调节端粒完整性的任何因子的失调将对染色体稳定性、复制寿命产生影响，并可能导致细胞转化。本文综述了参与端粒正常功能的主要因素以及这些因素是如何通过泛素和SUMO系统进行调节的。越来越多的证据表明，泛素和SUMO途径是shelterin复合物和其他染色质修饰剂的重要调节剂，这对端粒结构的完整性很重要。此外，这两条途径之间的串扰已被报道在端粒DNA修复。更好地了解端粒生物学的因素以及它们是如何调节的，对于设计癌症治疗和再生医学的新策略非常重要。
Telomeres are a unique structure of DNA repeats covered by proteins at the ends of the chromosomes that protect the coding regions of the genome and function as a biological clock. They require a tight regulation of the factors covering and protecting their structure, as they are shortened with each cell division to limit the ability of cells to replicate uncontrollably. Additionally, they protect the chromosome ends from DNA damage responses and thereby, prevent genomic instability. Telomere dysfunction can lead to chromosomal abnormalities and cancer. Therefore, dysregulation of any of the factors that regulate the integrity of the telomeres will have implications to chromosomal stability, replicative lifespan and may lead to cell transformation. This review will cover the main factors participating in the normal function of the telomeres and how these are regulated by the ubiquitin and SUMO systems. Accumulating evidence indicate that the ubiquitin and SUMO pathways are significant regulators of the shelterin complex and other chromatin modifiers, which are important for telomere structure integrity. Furthermore, the crosstalk between these two pathways has been reported in telomeric DNA repair. A better understanding of the factors contributing to telomere biology, and how they are regulated, is important for the design of new strategies for cancer therapies and regenerative medicine.
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影响因子：
64.8
作者：
Chen, Liuh-Yow;Redon, Sophie;Lingner, Joachim
通讯作者：
Lingner, Joachim
影响因子：
56.9
作者：
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通讯作者：
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影响因子：
16.6
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影响因子：
3.8
作者：
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通讯作者：
Durocher D
影响因子：
4.5
作者：
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通讯作者：
Armanios M