Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration.
Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration.
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DOI：
10.1002/dneu.22826
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发表时间：
2021-05
影响因子：
3
通讯作者：
English AW
中科院分区：
文献类型：
--
作者：
Ward PJ;Davey RA;Zajac JD;English AW
Neuronal activity after nerve injury can enhance axon regeneration and the restoration of function. The mechanism for this enhancement relies in part on hormone receptors, and we previously demonstrated that systemic androgen receptor antagonism blocked the effect of exercise or electrical stimulation on enhancing axon regeneration after nerve injury in both sexes. Here, we tested the hypothesis that the site of this androgen receptor signaling is both neuronal and involves the classical, genomic signaling pathway. In vivo, dorsal root ganglion neurons successfully regenerate in response to activity-dependent neuronal activation, and conditional deletion of the DNA-binding domain of the androgen receptor in adults blocks this effect in males and females. Motoneurons in males and females also respond in this manner, but we also observed a sex difference. In vitro, cultured sensory dorsal root ganglion neurons respond to androgens via traditional androgen receptor signaling mechanisms leading to enhanced neurite growth and did not respond to a testosterone conjugate that is unable to cross the cell membrane. Given our previous observation of a requirement for activity-dependent androgen receptor signaling to promote regeneration in both sexes, we interpret our results to indicate that genomic neuronal androgen receptor signaling is required for activity-dependent axon regeneration in both sexes.
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影响因子：
4.2
作者：
Jaiswal PB;Tung JK;Gross RE;English AW
通讯作者：
English AW
影响因子：
4
作者：
Estrada, M;Uhlen, P;Ehrlich, BE
通讯作者：
Ehrlich, BE
影响因子：
5.3
作者：
Gordon, Tessa;Amirjani, Nasim;Chan, K. Ming
通讯作者：
Chan, K. Ming
影响因子：
4.8
作者：
MacLean, Helen E.;Chiu, W. S. Maria;Zajac, Jeffrey D.
通讯作者：
Zajac, Jeffrey D.
DOI：
10.1682/jrrd.2011.03.0033
发表时间：
2012-01-01
影响因子：
--
作者：
Foecking, Eileen M.;Fargo, Keith N.;Jones, Kathryn J.
通讯作者：
Jones, Kathryn J.