Reference values for 50-kHZ electrical impedance myography.

Reference values for 50-kHZ electrical impedance myography.
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50-kHz电阻抗的参考值。

DOI:
10.1002/mus.21075
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发表时间:
2008-09
期刊:
影响因子:
3.4
通讯作者:
Tarulli, Andrew W.
Tarulli, Andrew W.
中科院分区:
医学3区
文献类型:
--
作者:
Rutkove, Seward B.;Fogerson, Patricia M.;Garmirian, Lindsay P.;Tarulli, Andrew W.

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电阻抗肌图(EIM)是一种非侵入性和定量评估肌肉健康的方法,其中主要的结果参数,相位(θ),在病变状态下减少。为了创建一组正常参考值,我们对87名健康个体的5块肌肉进行了50 kHz的EIM,以θ为主要结果变量。由于数据分布大多偏斜,因此进行对数变换,并将所得数据拟合为二次函数。通过绘制每个肌肉的该曲线的下95%置信区间来设置正常的下限,然后确定特定年龄的参考值。我们发现数据的分布与其他神经生理参数相似。正常的下限很容易定义,相对较少的值低于建议的下限。通过使用市售的生物阻抗装置,这些值将允许其他研究人员探索50 kHz EIM在临床神经肌肉疾病研究中的应用。
Electrical impedance myography (EIM) is a method for non-invasively and quantitatively assessing muscle health, in which the major outcome parameter, phase (θ), decreases in diseased states. In order to create a set of normal reference values, we performed 50 kHz EIM in 5 muscles of 87 healthy individuals, using θ as the major outcome variable. Since the distributions of data were mostly skewed, logarithmic transformations were performed, and the resulting data were fitted to quadratic functions. The lower limit of normal was set by plotting the lower 95% confidence interval of this curve for each muscle and then identifying age-specific reference values. We found that the distribution of data was similar to that for other neurophysiologic parameters. The lower limit of normal was easily defined, and relatively few values fell below the proposed lower limit. By using commercially available bioimpedance devices, these values will allow other investigators to explore the application of 50 kHz EIM in clinical neuromuscular disease research.
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发表时间: 2006-10-01
影响因子: 3.2
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