Reduced Oxidative Stress in Hypoalbuminemic CAPD Patients
Reduced Oxidative Stress in Hypoalbuminemic CAPD Patients
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降低低蛋白血症 CAPD 患者的氧化应激
DOI：
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发表时间：
2000
影响因子：
2.8
通讯作者：
J. Park
中科院分区：
文献类型：
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作者：
Soon Bae Kim;W. Yang;W. Min;S. K. Lee;J. Park
目的白蛋白是血浆抗氧化剂之一。低白蛋白血症透析患者心血管疾病的高发生率可能与低血清白蛋白导致的抗氧化能力下降有关。我们评估了连续动态腹膜透析（CAPD）患者血清白蛋白与氧化应激标志物丙二醛（MDA）和总抗氧化能力（TAC）的关系。在这项横断面研究中，我们测量了66名CAPD患者和30名正常人血液中的MDA、TAC、白蛋白、尿酸（另一种重要的血浆抗氧化剂）、前白蛋白和c反应蛋白（CRP）。将22例白蛋白小于或等于3.5 g/dL的CAPD患者分为两组：实验组（n = 11），在每天重复输注20%白蛋白100 mL，连续7 d前后测定MDA、TAC、CRP。对照组（n = 11）在不输注白蛋白的情况下测量相同参数。结果CAPD患者白蛋白水平低于正常对照组，丙二醛、TAC、尿酸水平高于正常对照组。CAPD患者白蛋白与TAC、尿酸呈正相关。与我们的预期相反，CAPD患者白蛋白与MDA之间也存在正相关（r = 0.37, p = 0.004）。MDA与TAC呈正相关。尿酸与TAC相关。然而，它与MDA没有相关性。Log CRP与白蛋白呈负相关，与MDA、TAC无相关性。白蛋白前期与MDA、TAC、白蛋白、尿酸相关。重复输注结束时，实验组血清白蛋白由2.5±0.3 g/dL升高至3.6±0.2 g/dL （p < 0.001）。两组患者的MDA、TAC和CRP均未见变化。结论本研究提示CAPD患者脂质过氧化增加，这不是由于血浆抗氧化防御能力减弱所致。TAC升高主要是由尿酸升高引起的。低白蛋白血症患者MDA降低而非升高，且白蛋白输注对MDA水平没有影响，提示透析患者低白蛋白血症中频繁发生心血管疾病并非由于血清白蛋白低导致抗氧化能力下降。
Objective Albumin is one of the plasma antioxidants. The higher incidence of cardiovascular disease in dialysis patients with hypoalbuminemia may be related to decreased antioxidant capacity resulting from low serum albumin. We evaluated malondialdehyde (MDA), a marker of oxidative stress, and total antioxidant capacity (TAC) in relation to serum albumin in continuous ambulatory peritoneal dialysis (CAPD) patients. Patients and Methods In this cross-sectional study, we measured MDA, TAC, albumin, uric acid (another important plasma antioxidant), prealbumin, and C-reactive protein (CRP) in the blood of 66 CAPD patients and 30 normal controls. Twenty-two CAPD patients with albumin less than or equal to 3.5 g/dL were divided into two groups: In the experimental group (n = 11), MDA, TAC, and CRP were measured before and after repeated infusion of 20% albumin 100 mL daily for 7 days. In the control group (n = 11), the same parameters were measured without albumin infusion. Results CAPD patients had lower albumin and higher MDA, TAC, and uric acid than normal controls. There were positive correlations between albumin and TAC or uric acid in CAPD patients. Contrary to our expectation, there was also positive correlation between albumin and MDA in CAPD patients (r = 0.37, p = 0.004). MDA showed a positive correlation with TAC. Uric acid was correlated with TAC. It did not, however, show correlation with MDA. Log CRP was negatively correlated with albumin, but did not show correlation with MDA or TAC. Prealbumin was correlated with MDA, TAC, albumin, and uric acid. Serum albumin in the experimental group increased from 2.5 ± 0.3 g/dL to 3.6 ± 0.2 g/dL (p < 0.001) at the end of repeated infusions. No changes were seen in MDA, TAC, and CRP in either group. Conclusions The present study suggests that lipid peroxidation is increased in CAPD patients and that this is not due to weakening of antioxidant defenses of plasma. Increased TAC was mainly caused by a higher level of uric acid. Reduced, rather than increased, MDA in hypoalbuminemic patients and lack of effects of albumin infusion on levels of MDA suggest that the frequent occurrence of cardiovascular disease in dialysis patients with hypoalbuminemia is not due to the decrease in antioxidant capacity resulting from low serum albumin.
游离脂肪酸对超氧化物释放和人中性粒细胞形状变化的影响。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Badwey,JA;Curnutte,JT;Robinson,JM;Berde,CB;Karnovsky,MJ;Karnovsky,ML
通讯作者：
Karnovsky,ML