Predictive Value of Degranulating Factors of Neutrophils in Massive Cerebral Infarction.
Predictive Value of Degranulating Factors of Neutrophils in Massive Cerebral Infarction.
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DOI：
10.1177/09636897211004089
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发表时间：
2021-01
影响因子：
3.3
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Huang Y;Li F;Chen Z;Chen W;Fan L;Zheng Y;Han Z;Li L;Luo Y;Zhang Y
大面积脑梗死（MCI）是一种危及生命的疾病，可导致脑疝。神经元脱颗粒在早期参与缺血性损伤。探讨中性粒细胞脱颗粒因子对脑疝形成及MCI患者远期预后的预测作用，并探讨中性粒细胞脱颗粒与血脑屏障（BBB）损害的关系。本病例对照研究共纳入14例MCI患者，根据患者在5天内是否发生脑疝，将患者分为脑疝组和无脑疝组。以6个月时改良兰金量表（mRS）评分评估MCI患者的预后，作为主要终点。在第2天和第4天测定MCI患者血浆中的白色血细胞（WBC）和中性粒细胞的脱粒因子的组成。两组的基线特征相当。有无脑疝组神经功能评分及远期预后无差异，但脑疝组近期病死率较高（P < 0.05）。脑疝患者的WBC计数、中性粒细胞与淋巴细胞比率（NLR）和血浆髓过氧化物酶（MPO）水平均明显高于无脑疝患者（均P < 0.05）。MPO是脑疝的较好预测因子，NLR对MCI患者的预后具有上级预测价值。中性粒细胞脱颗粒可能在MCI期间的恶性脑疝中起重要作用。提示MPO和NLR可作为MCI患者脑疝及预后的预测指标。
Massive cerebral infarction (MCI) is a life-threatening disease and may lead to cerebral herniation. Neutrophil degranulation contributes to ischemic injury in the early stage. To investigate whether neutrophil degranulating factors can predict cerebral herniation and the long-term prognosis of patients with MCI and to investigate the relationship between neutrophil degranulation and blood brain barrier (BBB) damage. In this case-control study of 14 MCI patients, we divided the patients into a cerebral hernia group and no cerebral hernia group according to whether they developed cerebral herniation within 5 days. The prognosis of MCI patients was assessed using the Modified Rankin Scale (mRS) score at 6 months, which was the primary end point. The composition of white blood cells (WBC) and degranulating factors for neutrophils in the plasma of MCI patients was determined on days 2 and 4. Baseline characteristics were comparable in both groups. The neurological functional scores and long-term prognosis showed no difference between patients with or without cerebral herniation, while the mortality rate of the cerebral hernia group in the short term was higher (P < 0.05). The WBC count, neutrophil to lymphocyte ratio (NLR) and plasma myeloperoxidase (MPO) levels of patients with cerebral hernia were significantly higher than those of patients without cerebral hernia (all P < 0.05). MPO is a better predictor of cerebral herniation, and the NLR showed superior predictive value in the prognosis of MCI patients. neutrophil degranulation may play an important role in malignant cerebral hernia during MCI. These data suggest that, MPO and the NLR might be predictive factors for cerebral herniation and the prognosis of MCI patients.
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影响因子：
32.4
作者：
Campbell EL;Bruyninckx WJ;Kelly CJ;Glover LE;McNamee EN;Bowers BE;Bayless AJ;Scully M;Saeedi BJ;Golden-Mason L;Ehrentraut SF;Curtis VF;Burgess A;Garvey JF;Sorensen A;Nemenoff R;Jedlicka P;Taylor CT;Kominsky DJ;Colgan SP
通讯作者：
Colgan SP
缺血性中风和血管再通药物组织纤溶酶原激活剂会干扰抗菌吞噬细胞的功能。
影响因子：
9.3
作者：
Vogelgesang A;Lange C;Blümke L;Laage G;Rümpel S;Langner S;Bröker BM;Dressel A;Ruhnau J
通讯作者：
Ruhnau J
促阳性蛋白作为大脑梗塞中恶性脑水肿的生物标志物。
影响因子：
4.6
作者：
Zhang Y;Liu G;Wang Y;Su Y;Leak RK;Cao G
通讯作者：
Cao G
影响因子：
64.8
作者：
Rius, Jordi;Guma, Monica;Karin, Michael
通讯作者：
Karin, Michael
影响因子：
8.3
作者：
Otxoa-de-Amezaga, Amaia;Gallizioli, Mattia;Planas, Anna M.
通讯作者：
Planas, Anna M.