Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction.
Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction.
复制标题
促阳性蛋白作为大脑梗塞中恶性脑水肿的生物标志物。
DOI：
10.1038/s41598-018-19267-4
复制
发表时间：
2018-01-17
影响因子：
4.6
通讯作者：
Cao G
中科院分区：
文献类型：
--
作者：
Zhang Y;Liu G;Wang Y;Su Y;Leak RK;Cao G
本研究的目的是探讨降钙素原(PCT)能否作为大面积脑梗塞(MCI)患者恶性脑水肿的早期生物标志物。93例急性MCI患者根据脑突出1周内死亡或存活分为死亡组和存活组。对两组间实验室参数的差异进行单因素分析，如果影响因素有显著差异，则进行多因素Logistic回归分析。与存活组比较，死亡组发病48 h内脑梗塞面积扩大、体温升高、中性粒细胞计数、红细胞压积、神经元特异性烯醇化酶升高。多因素Logistic回归分析显示，PCT和中性粒细胞计数的优势比(OR)分别为1.830和1.235，提示PCT和中性粒细胞计数是影响死亡的两个独立危险因素。受试者工作特征曲线下面积PCT为0.754，大于中性粒细胞计数。因此，血清PCT水平和中性粒细胞计数均可作为预测MCI后早期恶性脑水肿的生物标志物，但PCT水平是预测恶性脑水肿的更好指标。
The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or survived within 1 week of cerebral herniation. Differences in laboratory parameters between these two groups were analyzed by univariate analysis, followed by multivariate logistic regression analyses if the influencing factors were significantly different. Compared with the survival group, the patients in the death group had a larger cerebral infarct area, higher body temperature, neutrophil counts, PCT level, and neuron-specific enolase (NSE) level within 48 h of onset. Multivariate logistic regression analyses revealed an odds ratio (OR) of 1.830 or 1.235 for PCT and neutrophil counts respectively, suggesting that PCT and neutrophil counts are two independent risk factors for death in MCI. The area under receiver operating characteristic (ROC) curve was 0.754 for PCT, larger than that for neutrophil counts. Thus, both serum PCT levels and neutrophil counts can be used as biomarkers to predict malignant cerebral edema at the early stages after MCI, but PCT levels are superior predictors of malignant cerebral edema.
登录
查看更多内容
影响因子：
39.3
作者：
Wheeler, JG;Mussolino, ME;Danesh, J
通讯作者：
Danesh, J
影响因子：
11.1
作者：
Leira, R.;Rodriguez-Yanez, M.;Castillo, J.
通讯作者：
Castillo, J.
影响因子：
5.1
作者：
Wang, Chao;Gao, Li;Li, Li-Hong
通讯作者：
Li, Li-Hong
影响因子：
8.3
作者：
Kim, Suk Jae;Choe, Yeon Hyeon;Bang, Oh Young
通讯作者：
Bang, Oh Young
C反应蛋白和长期缺血性中风预后。
DOI：
10.1016/j.jocn.2013.06.015
发表时间：
2014-04
期刊：
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
影响因子：
--
作者：
VanGilder RL;Davidov DM;Stinehart KR;Huber JD;Turner RC;Wilson KS;Haney E;Davis SM;Chantler PD;Theeke L;Rosen CL;Crocco TJ;Gutmann L;Barr TL
通讯作者：
Barr TL