The Toxins of Beauveria bassiana and the Strategies to Improve Their Virulence to Insects.
The Toxins of Beauveria bassiana and the Strategies to Improve Their Virulence to Insects.
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白僵菌毒素及提高其对昆虫毒力的策略
DOI：
10.3389/fmicb.2021.705343
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发表时间：
2021
影响因子：
5.2
通讯作者：
Gong M
中科院分区：
文献类型：
--
作者：
Wang H;Peng H;Li W;Cheng P;Gong M
长期和过度使用农药对环境造成巨大负担，也增加了害虫的抗药性。为解决这一问题，对环境友好且抗性较低的昆虫病原真菌的研究和应用得到了很大的发展。昆虫病原真菌具有广泛的前景。除苏云金芽孢杆菌外，球孢白僵菌是研究最多的生物农药。B.白僵菌产生多种毒素，这些毒素是次级代谢产物，例如白僵菌素、白僵菌内酯、tenellin、卵孢子素和草酸。这些毒素帮助B。白僵菌寄生并杀死寄主。本文综述了白僵菌毒素对昆虫免疫系统的作用机制，并对白僵菌毒素的研究前景进行了展望。基因工程策略以改进B的毒素原理、基因或毒性分子。也讨论了巴西纳。最后，我们讨论了未来的白僵菌毒素的研究，包括新发现的毒素。
The long-term and excessive usage of pesticides is an enormous burden on the environment, which also increases pest resistance. To overcome this problem, research and application of entomopathogenic fungi, which are both environmentally friendly and cause lower resistance, have gained great momentum. Entomopathogenic fungi have a wide range of prospects. Apart from Bacillus thuringiensis, Beauveria bassiana is the most studied biopesticide. After invading insect hosts, B. bassiana produces a variety of toxins, which are secondary metabolites such as beauvericin, bassianin, bassianolide, beauverolides, tenellin, oosporein, and oxalic acid. These toxins help B. bassiana to parasitize and kill the hosts. This review unequivocally considers beauveria toxins highly promising and summarizes their attack mechanism(s) on the host insect immune system. Genetic engineering strategies to improve toxin principles, genes, or virulent molecules of B. bassiana have also been discussed. Lastly, we discuss the future perspective of Beauveria toxin research, including newly discovered toxins.
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DOI：
10.1073/pnas.0606146103
发表时间：
2006-12-12
影响因子：
11.1
作者：
Borovsky, Dov;Rabindran, Shailaja;DeLoof, Arnold
通讯作者：
DeLoof, Arnold
影响因子：
4
作者：
Fernandes, E. K. K.;Keyser, C. A.;Roberts, D. W.
通讯作者：
Roberts, D. W.
影响因子：
3.4
作者：
Fuguet, R;Vey, A
通讯作者：
Vey, A
影响因子：
2.2
作者：
Glare, Travis;Campbell, Matt;Cox, Murray
通讯作者：
Cox, Murray
影响因子：
4.8
作者：
Huang, Wei;Shang, Yanfang;Wang, Chengshu
通讯作者：
Wang, Chengshu