Role of the immunogenic and tolerogenic subsets of dendritic cells in multiple sclerosis.
Role of the immunogenic and tolerogenic subsets of dendritic cells in multiple sclerosis.
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树突状细胞的免疫原性和耐受性子集在多发性硬化症中的作用。
DOI：
10.1155/2015/513295
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发表时间：
2015
影响因子：
4.6
通讯作者：
Jin T
中科院分区：
文献类型：
--
作者：
Xie ZX;Zhang HL;Wu XJ;Zhu J;Ma DH;Jin T
多发性硬化（MS）是中枢神经系统（CNS）中的免疫介导的疾病，其特征在于炎症和脱髓鞘以及轴突和神经元变性。迄今为止，仍缺乏有效的治疗方法来逆转这种疾病;大多数治疗药物只能改善症状或减少复发频率。树突状细胞（Dendritic cells，DC）是专职抗原呈递细胞（antigen presenting cells，APC），在介导免疫应答和诱导免疫耐受中起关键作用。越来越多的证据表明，DC有助于MS的发病机制，并可能提供一种治疗干预的途径。本文综述了DC在MS中的免疫原性和耐受性作用，并对可能影响DC功能的药物和临床上用于MS治疗的药物进行了综述。我们还描述了潜在的治疗分子，可以通过诱导抗炎细胞因子和抑制MS中的促炎细胞因子来靶向DC。
Multiple sclerosis (MS) is an immune-mediated disorder in the central nervous system (CNS) characterized by inflammation and demyelination as well as axonal and neuronal degeneration. So far effective therapies to reverse the disease are still lacking; most therapeutic drugs can only ameliorate the symptoms or reduce the frequency of relapse. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that are key players in both mediating immune responses and inducing immune tolerance. Increasing evidence indicates that DCs contribute to the pathogenesis of MS and might provide an avenue for therapeutic intervention. Here, we summarize the immunogenic and tolerogenic roles of DCs in MS and review medicinal drugs that may affect functions of DCs and have been applied in clinic for MS treatment. We also describe potential therapeutic molecules that can target DCs by inducing anti-inflammatory cytokines and inhibiting proinflammatory cytokines in MS.
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