Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system.
Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system.
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DOI：
10.1016/j.bbr.2010.06.025
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发表时间：
2010-12-25
影响因子：
2.7
通讯作者：
Blanchard, Robert J.
中科院分区：
文献类型：
--
作者：
Pobbe, Roger L. H.;Pearson, Brandon L.;Defensor, Erwin B.;Bolivar, Valerie J.;Blanchard, D. Caroline;Blanchard, Robert J.
自闭症谱系障碍(ASD)的核心症状包括社交障碍、沟通障碍和具有受限兴趣的重复行为。具有与这些核心症状相关的行为表型的小鼠模型为推进ASD相关基因的研究提供了一种实验方法。以前的研究结果表明，BTBR T+Tf/J(BTBR)是一种近交系小鼠，表现出与ASD的所有三种诊断症状相似的强健行为表型。在本研究中，我们研究了在半自然可见洞穴系统(VBS)中，由三只相同品系的成年雄性小鼠(C57BL/6J(B6)或BTBR)组成的群体在克隆形成和维持期间的社会行为的表达。为了进行比较，随后使用了一项广泛调查的三室试验来评估两个菌株的社交方式。紧张对这两种情况的影响是一致的，而且非常显著。在VBS中，与B6相比，BTBR小鼠在所有互动行为方面都有所减少：接近(前面和后面)、飞行、追逐/跟随、异类打扮和抱团，而自我打扮和独自一人的行为增加。这些结果在三室测试中得到了证实：与B6相比，雄性BTBR小鼠没有在装有陌生CD-1小鼠的测试箱一侧花费更多时间。总体而言，目前的数据表明，BTBR小鼠的品系特征，包括持续的社会缺陷和高水平的重复自我修饰，模拟了ASD表型的多个组成部分。
The core symptoms of autism spectrum disorder (ASD) include deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Mouse models with behavioral phenotypes relevant to these core symptoms offer an experimental approach to advance the investigation of genes associated with ASD. Previous findings demonstrate that BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of ASD. In the present study, we investigated the expression of social behaviors in a semi-natural visible burrow system (VBS), during colony formation and maintenance in groups comprising three adult male mice of the same strain, either C57BL/6J (B6) or BTBR. For comparative purposes, an extensively investigated three-chambered test was subsequently used to assess social approach in both strains. The effects of strain on these two situations were consistent and highly significant. In the VBS, BTBR mice showed reductions in all interactive behaviors: approach (front and back), flight, chase/follow, allo-grooming and huddling, along with increases in self-grooming and alone, as compared to B6. These results were corroborated in the three-chambered test: in contrast to B6, male BTBR mice failed to spend more time in the side of the test box containing the unfamiliar CD-1 mouse. Overall, the present data indicates that the strain profile for BTBR mice, including consistent social deficits and high levels of repetitive self-grooming, models multiple components of the ASD phenotype.
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影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
2.5
作者：
McFarlane, H. G.;Kusek, G. K.;Crawley, J. N.
通讯作者：
Crawley, J. N.
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
影响因子：
2.9
作者：
Blanchard, RJ;Dullogg, L;Blanchard, DC
通讯作者：
Blanchard, DC
影响因子：
4
作者：
Dawson, G;Toth, K;Liaw, J
通讯作者：
Liaw, J