Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.

Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.
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DOI:
10.1016/j.tracli.2015.12.003
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发表时间:
2016-02
期刊:
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
影响因子:
--
通讯作者:
Laperche S
Laperche S
中科院分区:
其他
文献类型:
--
作者:
Garraud O;Heshmati F;Pozzetto B;Lefrere F;Girot R;Saillol A;Laperche S

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血浆治疗包括向有需要的患者(通常患有严重的、对当前治疗有耐药性的,甚至是致命的感染)提供血浆或特异性的、分离的抗体,以及可从免疫献血者处获得的其他免疫球蛋白和可能的愈合因子;捐赠者(自愿和慈善)既可以是积极免疫的个人,也可以是恢复期的人。自1917年至1918年的西班牙流感以来,血浆疗法一直在使用,当病毒流行威胁到脆弱人群时,也会定期使用,最近一次报道的病例是2013年至2015年西非埃博拉病毒爆发。血浆治疗的确切作用机制尚不完全清楚,因为它的作用可能超出纯化的中和抗体。
Plasma therapy consists in bringing to a patient in need – in general suffering a severe, resistant to current therapy, and even lethal infection – plasma or specific, fractioned, antibodies, along with other immunoglobulins and possibly healing factors that can be obtained from immunized blood donors; donors (voluntary and benevolent) can be either actively immunized individuals or convalescent persons. Plasma therapy has been used since the Spanish flu in 1917–1918, and regularly then when viral epidemics threatened vulnerable populations, the last reported occurrence being the 2013–2015 Ebola virus outbreak in West Africa. The precise action mechanism of plasma therapy is not fully delineated as it may function beyond purified, neutralizing antibodies.
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