Synthetic routes to trifluoromethylphenyl diazirine photolabeling reagents containing an alkyne substituent (TPDYNE) for chemical biology applications.
Synthetic routes to trifluoromethylphenyl diazirine photolabeling reagents containing an alkyne substituent (TPDYNE) for chemical biology applications.
复制标题
作者：
The trifluoromethylphenyl diazirine (TPD) group is widely used in photoaffinity labeling studies. The TPDYNE group (TPD with an additional alkyne substituent on the phenyl ring) enables the use of click chemistry in conjunction with photoaffinity labeling and expands the utility of the TPD group. New methods for preparing previously known as well as new TPDYNE reagents are reported. Additional methods for preparation of a TPDYNE precursor from which the TPDYNE group can be generated once the precursor is attached to the molecule of interest are also described. Procedures for attaching the TPDYNE or TPDYNE precursor to carboxyl, amino, hydroxyl and alkyne groups are demonstrated using steroids as examples. Click photolabeling reagents and presursors for chemical biology applications.
登录
查看更多内容
影响因子：
--
作者：
Cerny, I;Budesínsky, M;Drasar, P
通讯作者：
Drasar, P
影响因子：
3.5
作者：
Kumar, Nag S.;Young, Robert N.
通讯作者：
Young, Robert N.
影响因子：
9.8
作者：
Chen, Zi-Wei;Bracamontes, John R.;Evers, Alex S.
通讯作者：
Evers, Alex S.
影响因子：
2.7
作者：
Hosoya, T;Hiramatsu, T;Suzuki, M
通讯作者：
Suzuki, M
影响因子：
4
作者：
Krishnan K;Qian M;Feltes M;Chen ZW;Gale S;Wang L;Sugasawa Y;Reichert DE;Schaffer JE;Ory DS;Evers AS;Covey DF
通讯作者：
Covey DF