Treatment of echinococcosis: albendazole and mebendazole--what else?
Treatment of echinococcosis: albendazole and mebendazole--what else?
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DOI：
10.1051/parasite/2014073
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gottstein B
中科院分区：
文献类型：
--
作者：
Hemphill A;Stadelmann B;Rufener R;Spiliotis M;Boubaker G;Müller J;Müller N;Gorgas D;Gottstein B
由于多房棘球蚴的后囊蚴，正在寻找治疗泡状棘球蚴病（AE）的新治疗方案，这些进展也可能对治疗由密切相关的细粒棘球蚴引起的囊性棘球蚴病（CE）产生深远影响。目前正在探讨若干备选办法。一个可行的策略，用于识别新的化疗有价值的化合物，包括全生物体药物筛选，采用大规模的体外后绦虫培养，并在确定有前途的化合物，在小实验室动物的药物疗效的验证。显然，目前的重点是针对广谱抗寄生虫或抗癌药物和化合物类，已经上市，或正在开发的其他应用。全面的棘球绦虫基因组信息和基因表达数据的可用性，以及在分子水平上的重大进展，现在已经为更有针对性的药物发现方法打开了大门，该方法允许利用寄生虫所必需的定义的途径和酶。此外，目前用于评估药物疗效的体外和体内模型应得到优化，并补充有关药物治疗期间发生的宿主-寄生虫相互作用的更详细信息的方法。成功的关键是识别、靶向和利用那些对寄生虫生存至关重要的寄生虫分子。
The search for novel therapeutic options to cure alveolar echinococcosis (AE), due to the metacestode of Echinococcus multilocularis, is ongoing, and these developments could also have a profound impact on the treatment of cystic echinococcosis (CE), caused by the closely related Echinococcus granulosus s.l. Several options are being explored. A viable strategy for the identification of novel chemotherapeutically valuable compounds includes whole-organism drug screening, employing large-scale in vitro metacestode cultures and, upon identification of promising compounds, verification of drug efficacy in small laboratory animals. Clearly, the current focus is targeted towards broad-spectrum anti-parasitic or anti-cancer drugs and compound classes that are already marketed, or that are in development for other applications. The availability of comprehensive Echinococcus genome information and gene expression data, as well as significant progress on the molecular level, has now opened the door for a more targeted drug discovery approach, which allows exploitation of defined pathways and enzymes that are essential for the parasite. In addition, current in vitro and in vivo models that are used to assess drug efficacy should be optimized and complemented by methods that give more detailed information on the host-parasite interactions that occur during drug treatments. The key to success is to identify, target and exploit those parasite molecules that orchestrate activities essential to parasite survival.
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影响因子：
1.9
作者：
Kern, P
通讯作者：
Kern, P
影响因子：
4.9
作者：
Kuester, Tatiana;Stadelmann, Britta;Hemphill, Andrew
通讯作者：
Hemphill, Andrew
影响因子：
5.8
作者：
Gelmedin, Verena;Caballero-Gamiz, Rocio;Brehm, Klaus
通讯作者：
Brehm, Klaus
DOI：
10.1080/00034983.1983.11811742
发表时间：
1983-01-01
影响因子：
--
作者：
ALIKHAN, Z;SIBOO, R;FAUCHER, M
通讯作者：
FAUCHER, M
影响因子：
2.1
作者：
Fernández, V;Chalar, C;Fernández, C
通讯作者：
Fernández, C