Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.
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DOI：
10.1016/j.canlet.2014.04.003
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发表时间：
2014-07-10
期刊：
影响因子：
9.7
通讯作者：
Buchsbaum, Donald J.
中科院分区：
文献类型：
--
作者：
Li, Yonghe;Li, Pui-Kai;Roberts, Michael J.;Arend, Rebecca C.;Samant, Rajeev S.;Buchsbaum, Donald J.
快速开发安全有效的新型抗癌药物是基础科学家、临床医生和患者共同的目标。当前的综述讨论了一种这样的药物，即氯硝柳胺，它已在临床上用于治疗肠道寄生虫感染。最近的研究通过各种高通量筛选活动反复确认氯硝柳胺是一种潜在的抗癌药物。 Niclosamide 不仅抑制 Wnt/β-catenin、mTORC1、STAT3、NF-κB 和 Notch 信号通路，而且还靶向癌细胞中的线粒体，诱导细胞周期停滞、生长抑制和细胞凋亡。许多研究已经在体外和体内模型中确定了氯硝柳胺的抗癌活性。此外，氯硝柳胺对癌症干细胞的抑制作用为其作为一种有前景的癌症治疗药物提供了进一步的证据。本文综述了氯硝柳胺的各个方面，因为它们与其抗癌功效和相关分子机制有关。
The rapid development of new anticancer drugs that are safe and effective is a common goal shared by basic scientists, clinicians and patients. The current review discusses one such agent, namely niclosamide, which has been used in the clinic for the treatment of intestinal parasite infections. Recent studies repeatedly identified niclosamide as a potential anticancer agent by various high-throughput screening campaigns. Niclosamide not only inhibits the Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways, but also targets mitochondria in cancer cells to induce cell cycle arrest, growth inhibition and apoptosis. A number of studies have established the anticancer activities of niclosamide in both in vitro and in vivo models. Moreover, the inhibitory effects of niclosamide on cancer stem cells provide further evidence for its consideration as a promising drug for cancer therapy. This article reviews various aspects of niclosamide as they relate to its efficacy against cancer and associated molecular mechanisms.
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影响因子：
4.2
作者：
Chen, Haijun;Yang, Zhengduo;Ding, Chunyong;Chu, Lili;Zhang, Yusong;Terry, Kristin;Liu, Huiling;Shen, Qiang;Zhou, Jia
通讯作者：
Zhou, Jia
DOI：
10.1038/nrm3522
发表时间：
2013-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Balgi AD;Fonseca BD;Donohue E;Tsang TC;Lajoie P;Proud CG;Nabi IR;Roberge M
通讯作者：
Roberge M
影响因子：
64.5
作者：
Gupta PB;Onder TT;Jiang G;Tao K;Kuperwasser C;Weinberg RA;Lander ES
通讯作者：
Lander ES
影响因子：
11.2
作者：
Jin, Yanli;Lu, Zhongzheng;Pan, Jingxuan
通讯作者：
Pan, Jingxuan