Voluntary exercise blocks ongoing pain and diminishes bone remodeling while sparing protective mechanical pain in a rat model of advanced osteoarthritis pain.
Voluntary exercise blocks ongoing pain and diminishes bone remodeling while sparing protective mechanical pain in a rat model of advanced osteoarthritis pain.
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DOI：
10.1097/j.pain.0000000000002392
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发表时间：
2022-03-01
期刊：
影响因子：
7.4
通讯作者：
King T
中科院分区：
文献类型：
--
作者：
Townsend K;Imbert I;Eaton V;Stevenson GW;King T
运动是医疗保健提供者推荐的治疗肌肉骨骼疼痛的最常见的治疗方法。我们研究了自主跑轮运动是否能改善碘乙酸钠诱导的单侧膝关节疼痛大鼠的疼痛和骨重塑。在骨关节炎（OA）治疗前的轮跑习得过程中，将大鼠分为两组，以距离和峰值速度为特征，分别为高水平或低水平的轮跑。在诱导膝关节OA后，所有大鼠在整个研究过程中都表现出自发性轮毂运动减弱。在研究的任何时间点上，自愿滚轮跑都不能改变被评价为体重不对称或后爪触觉阈值的诱发伤害性反应。相比之下，利多卡因注射到高跑而非低跑的大鼠经碘酸钠治疗的膝关节后产生的条件性位置偏好证明了持续疼痛的缓解。与久坐不动的对照组相比，高强度和低强度自愿跑步者的小梁骨丢失都有所减少。这些观察结果表明，高强度和低强度运动都有利于防止晚期OA患者的骨重塑。数据表明，与临床观察相似，骨重塑与疼痛无关。此外，这些结果表明，高强度的运动可以缓解持续的OA疼痛，同时保持运动引起的伤害感觉。持续疼痛的缓解可以潜在地显著改善生活质量，而保持对运动引起的疼痛的反应对于保护关节免受过度使用造成的损伤尤为重要。
Exercise is the most common treatment recommended by healthcare providers for the treatment of musculoskeletal pain. We examined whether voluntary running wheel exercise improves pain and bone remodeling in rats with monosodium iodoacetate–induced unilateral knee joint pain. During acquisition of wheel running before osteoarthritis (OA) treatment, rats separated into 2 groups characterized by either high or low levels of voluntary wheel running as indicated by distance and peak speed. After the induction of knee joint OA, all rats showed diminished voluntary wheel running throughout the study. Voluntary wheel running failed to alter evoked nociceptive responses evaluated as weight asymmetry or hind paw tactile thresholds at any timepoint of the study. By contrast, relief of ongoing pain was demonstrated by conditioned place preference produced by lidocaine injection into the monosodium iodoacetate–treated knee in high but not low-running rats. Both high and low voluntary runners showed diminished trabecular bone loss compared with sedentary controls. These observations indicate that both high-intensity and low-intensity exercise is beneficial in protecting against bone remodeling in advanced OA. The data suggest that similar to clinical observation, bone remodeling does not correlate with pain. In addition, these results suggest that higher intensity exercise may relieve persistent ongoing OA pain while maintaining movement-evoked nociception. The relief of ongoing pain can potentially offer significant improvement in quality of life, whereas preservation of responses to movement-evoked pain may be especially important in protecting the joint from damage because of overuse.
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影响因子：
2.8
作者：
Cooper, Nicholas A.;Rakel, Barbara A.;Sluka, Kathleen A.
通讯作者：
Sluka, Kathleen A.
影响因子：
7
作者：
Hawker, G. A.;Stewart, L.;Gooberman-Hill, R.
通讯作者：
Gooberman-Hill, R.
影响因子：
4.3
作者：
Cooper MA;Kluding PM;Wright DE
通讯作者：
Wright DE
影响因子：
7.4
作者：
Bobinski F;Teixeira JM;Sluka KA;Santos ARS
通讯作者：
Santos ARS
DOI：
10.1002/art.40101
发表时间：
2017-07
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Allen J;Imbert I;Havelin J;Henderson T;Stevenson G;Liaw L;King T
通讯作者：
King T