SARS-CoV-2 reinfection prevents acute respiratory disease in Syrian hamsters but not replication in the upper respiratory tract.
SARS-CoV-2 reinfection prevents acute respiratory disease in Syrian hamsters but not replication in the upper respiratory tract.
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DOI：
10.1016/j.celrep.2022.110515
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发表时间：
2022-03-15
期刊：
影响因子：
8.8
通讯作者：
Feldmann H
中科院分区：
文献类型：
--
作者：
Hansen F;Meade-White K;Clancy C;Rosenke R;Okumura A;Hawman DW;Feldmann F;Kaza B;Jarvis MA;Rosenke K;Feldmann H
Human cases of SARS-CoV-2 reinfection have been documented throughout the pandemic, but are likely under-reported. In the current study, we use the Syrian hamster SARS-CoV-2 model to assess reinfection with homologous WA1 and heterologous B.1.1.7 (Alpha) and B.1.351 (Beta) SARS-CoV-2 variants over time. Upon primary infection with SARS-CoV-2 WA1, hamsters rapidly develop a strong and long-lasting humoral immune response. After reinfection with homologous and heterologous SARS-CoV-2 variants, this immune response protects hamsters from clinical disease, virus replication in the lower respiratory tract, and acute lung pathology. However, reinfection leads to SARS-CoV-2 replication in the upper respiratory tract with the potential for virus shedding. Our findings indicate that reinfection results in restricted SARS-CoV-2 replication despite substantial levels of humoral immunity, denoting the potential for transmission through reinfected asymptomatic individuals. Hansen et al. show that SARS-CoV-2 infection of hamsters results in an acute pulmonary disease and that hamsters develop a strong, durable antibody response with lesions consistent with alveolar bronchiolization. SARS-CoV-2 reinfection results in low levels of viral replication in the upper respiratory tract and protection from acute respiratory disease
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