Heritable hazards of smoking: Applying the "clean sheet" framework to further science and policy.
Heritable hazards of smoking: Applying the "clean sheet" framework to further science and policy.
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DOI：
10.1002/em.22412
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发表时间：
2020-11
影响因子：
2.8
通讯作者：
Workshop Presenters
中科院分区：
文献类型：
--
作者：
Bline AP;Dearfield KL;DeMarini DM;Marchetti F;Yauk CL;Escher J;Workshop Presenters
我们体内的所有细胞都来自我们父母的生殖细胞，就像我们自己的生殖细胞成为我们孩子的身体一样。从这些生殖细胞继承的遗传信息的完整性对于建立每一代人的健康和将我们的物种延续到未来是至关重要的。有大量不断增长的证据有力地表明，存在可能通过充当人类生殖细胞诱变剂而威胁到这种完整性的物质的存在。然而，通常没有绝对的监管要求来测试试剂对生殖细胞的影响。此外，目前的监管测试范式没有评估表观遗传中介的代际效应的影响，也没有监管框架来在监管决策中应用新的和新兴的测试。2019年9月，在华盛顿特区举行的环境突变和基因组学会第50届年会上，举办了一个研讨会，以烟草烟雾为例，研究了有害暴露于生殖细胞的可遗传影响。本概要概述了研讨会上确定的烟草烟雾暴露的可遗传危害所关注的领域，以及清洁表框架在组织信息以解决知识和测试差距方面的价值。
All the cells in our bodies are derived from the germ cells of our parents, just as our own germ cells become the bodies of our children. The integrity of the genetic information inherited from these germ cells is of paramount importance in establishing the health of each generation and perpetuating our species into the future. There is a large and growing body of evidence strongly suggesting the existence of substances that may threaten this integrity by acting as human germ cell mutagens. However, there generally are no absolute regulatory requirements to test agents for germ cell effects. In addition, the current regulatory testing paradigms do not evaluate the impacts of epigenetically mediated intergenerational effects, and there is no regulatory framework to apply new and emerging tests in regulatory decision making. At the 50th annual meeting of the Environmental Mutagenesis and Genomics Society held in Washington, DC, in September 2019, a workshop took place that examined the heritable effects of hazardous exposures to germ cells, using tobacco smoke as the example hazard. This synopsis provides a summary of areas of concern regarding heritable hazards from tobacco smoke exposures identified at the workshop and the value of the Clean Sheet framework in organizing information to address knowledge and testing gaps.
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影响因子：
9.8
作者：
Joubert, Bonnie R.;Felix, Janine F.;London, Stephanie J.
通讯作者：
London, Stephanie J.
影响因子：
2.8
作者：
Johnson GE;Soeteman-Hernández LG;Gollapudi BB;Bodger OG;Dearfield KL;Heflich RH;Hixon JG;Lovell DP;MacGregor JT;Pottenger LH;Thompson CM;Abraham L;Thybaud V;Tanir JY;Zeiger E;van Benthem J;White PA
通讯作者：
White PA
影响因子：
4.8
作者：
Laubenthal, Julian;Zlobinskaya, Olga;Anderson, Diana
通讯作者：
Anderson, Diana
影响因子：
9.6
作者：
Li, YF;Langholz, B;Gilliland, FD
通讯作者：
Gilliland, FD
影响因子：
4.6
作者：
Golding J;Ellis G;Gregory S;Birmingham K;Iles-Caven Y;Rai D;Pembrey M
通讯作者：
Pembrey M