Cell signaling pathways in vertebrate lens regeneration.

Cell signaling pathways in vertebrate lens regeneration.
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DOI:
10.1007/82_2012_289
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发表时间:
2013
影响因子:
--
通讯作者:
Perry, Kimberly J.
Perry, Kimberly J.
中科院分区:
医学3区
文献类型:
--
作者:
Henry, Jonathan J.;Thomas, Alvin G.;Hamilton, Paul W.;Moore, Lisa;Perry, Kimberly J.

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某些脊椎动物能够再生眼睛的某些部分,包括透镜。根据物种的不同,已经描述了体内透镜再生的两种主要形式,其中新的透镜来自虹膜背侧的色素上皮或角膜上皮。这些形式的透镜再生是由眼睛中存在的视网膜因子触发的。研究已经开始阐明支持透镜再生的信号的性质。本文综述了参与透镜再生的特定信号通路的证据,包括FGF,视黄酸,TGF-β,Wnt和刺猬途径。
Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regeneration are triggered by retinal factors present in the eye. Studies have begun to illuminate the nature of the signals that support lens regeneration. This review describes evidence for the involvement of specific signaling pathways in lens regeneration, including the FGF, retinoic acid, TGF-beta, Wnt and hedgehog pathways.
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