Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography.
Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography.
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DOI：
10.1117/1.jbo.26.8.086005
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发表时间：
2021-08
影响因子：
3.5
通讯作者：
Wong BJ
中科院分区：
文献类型：
--
作者：
Sharma GK;Chen LY;Chou L;Badger C;Hong E;Rangarajan S;Chang TH;Armstrong WB;Verma SP;Chen Z;Ramalingam R;Wong BJ
意义：人类声带(VF)在多个矢量中振荡，并由不同的层组成，这些层具有不同的粘弹性属性，这些层对粘膜波有贡献。基于办公室的和手术喉内窥镜检查仅限于对VF上皮表面的诊断评估，并限于水平粘膜波的轴面特征。因此，对人体室颤运动的生物力学的了解仍然有限。目的：光学相干层析成像(OCT)是一种微米级分辨率的高速内窥镜成像技术，可获得组织的横断面图像。我们的研究旨在利用OCT技术，开发定量方法来分析活体VF在冠状平面内的运动和解剖学。方法：使用定制的手持喉台，以250 GHz频率采集800个A线的OCT图像。开发了自动图像后处理和分析方法。结果：报道了对清醒受试者振动的室颤进行活体、远程OCT成像的新的运动学分析。介绍了发声过程中喉部的横断面、冠状平面全景视频，以及室颤运动的三维运动图像和空间-时间速度分析。结论：使用自动计算方法的远程OCT允许横断面动态喉部成像，并有可能拓宽我们对人类VF生物力学和声音产生的理解。
Significance: The human vocal fold (VF) oscillates in multiple vectors and consists of distinct layers with varying viscoelastic properties that contribute to the mucosal wave. Office-based and operative laryngeal endoscopy are limited to diagnostic evaluation of the VF epithelial surface only and are restricted to axial-plane characterization of the horizontal mucosal wave. As such, understanding of the biomechanics of human VF motion remains limited. Aim: Optical coherence tomography (OCT) is a micrometer-resolution, high-speed endoscopic imaging modality which acquires cross-sectional images of tissue. Our study aimed to leverage OCT technology and develop quantitative methods for analyzing the anatomy and kinematics of in vivo VF motion in the coronal plane. Approach: A custom handheld laryngeal stage was used to capture OCT images with 800 A-lines at 250 Hz. Automated image postprocessing and analytical methods were developed. Results: Novel kinematic analysis of in vivo, long-range OCT imaging of the vibrating VF in awake human subjects is reported. Cross-sectional, coronal-plane panoramic videos of the larynx during phonation are presented with three-dimensional videokymographic and space-time velocity analysis of VF motion. Conclusions: Long-range OCT with automated computational methods allows for cross-sectional dynamic laryngeal imaging and has the potential to broaden our understanding of human VF biomechanics and sound production.
影响因子：
3.5
作者：
Guo S;Yu L;Sepehr A;Perez J;Su J;Ridgway JM;Vokes D;Wong BJ;Chen Z
通讯作者：
Chen Z