Does regulation of skeletal muscle function involve circulating microRNAs?
Does regulation of skeletal muscle function involve circulating microRNAs?
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DOI：
10.3389/fphys.2014.00039
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发表时间：
2014
影响因子：
4
通讯作者：
Sakuma K
中科院分区：
文献类型：
--
作者：
Aoi W;Sakuma K
microRNA（miRNAs）是一类参与转录后基因调控的非编码小RNA。最近，越来越多的证据表明，miRNA被细胞内的外泌体吸收，分泌到循环中，并被其他细胞吸收。在癌症、糖尿病和心血管疾病等疾病中，几种miRNA的循环水平发生变化;因此，它们被认为通过调节蛋白质表达来调节受体细胞的功能。循环miRNA（c-miRNA）也可以在生理和病理条件下调节骨骼肌功能。已经表明，急性和慢性运动瞬时或适应性地改变c-miRNA的水平，从而转录后调节与能量代谢、肌生成和血管生成相关的蛋白质。肌肉中富集的几种miRNA的循环水平在肌肉疾病中改变，并且可能参与其发展和进展。此外，这样的c-miRNAs可以用作生物标志物，以确定组织之间的各种相互作用，并且还反映运动表现、身体疲劳、发病风险和疾病的发展。
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Recently, growing evidence has shown that miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by other cells. Circulating levels of several miRNAs are changed in diseases such as cancer, diabetes, and cardiovascular diseases; therefore, they are suggested to regulate functions of the recipient cells by modulating protein expression. Circulating miRNAs (c-miRNAs) may also modulate skeletal muscle function in physiological and pathological conditions. It has been suggested that acute and chronic exercise transiently or adaptively changes the level of c-miRNAs, thus post-transcriptionally regulating proteins associated with energy metabolism, myogenesis, and angiogenesis. Circulating levels of several miRNAs that are enriched in muscle are altered in muscle disorders and may be involved in their development and progression. In addition, such c-miRNAs may be useful as biomarkers to determine various interactions between tissues and also to reflect athletic performance, physical fatigue, incidence risk, and development of diseases.
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影响因子：
3.7
作者：
Cardinali B;Castellani L;Fasanaro P;Basso A;Alemà S;Martelli F;Falcone G
通讯作者：
Falcone G
DOI：
10.1083/jcb.200603008
发表时间：
2006-08-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kim HK;Lee YS;Sivaprasad U;Malhotra A;Dutta A
通讯作者：
Dutta A
影响因子：
3.7
作者：
Bye A;Røsjø H;Aspenes ST;Condorelli G;Omland T;Wisløff U
通讯作者：
Wisløff U
影响因子：
--
作者：
Agaoglu, Fulya Yaman;Kovancilar, Muge;Gezer, Ugur
通讯作者：
Gezer, Ugur
影响因子：
9
作者：
Kanaan, Ziad;Rai, Shesh N.;Galandiuk, Susan
通讯作者：
Galandiuk, Susan