Circulating microRNAs and aerobic fitness--the HUNT-Study.
Circulating microRNAs and aerobic fitness--the HUNT-Study.
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DOI：
10.1371/journal.pone.0057496
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wisløff U
中科院分区：
文献类型：
--
作者：
Bye A;Røsjø H;Aspenes ST;Condorelli G;Omland T;Wisløff U
有氧适能以最大摄氧量 (VO2max) 来衡量，是心血管健康的良好指标，也是心血管死亡率的有力预测指标。因此，与低摄氧量相关的生物标志物可能代表未来心血管疾病 (CVD) 的潜在早期标志物。本研究的目的是评估循环 microRNA (miR) 是否与健康个体的 VO2max 水平相关。在一项筛选研究中，在健康个体（40-45 岁）的血清样本中测量了 720 个 miR，这些个体具有与性别、年龄和体力活动相匹配的高摄氧量 (n = 12) 或低摄氧量 (n = 12)。候选 miR 在第二组具有高 (n = 38) 或低 (n = 38) VO2max 的受试者中进行了验证。发现 miR-210 和 miR-222 在低 VO2max 组中较高（p<0.05）。此外，最大摄氧量较低的男性参与者中 miR-21 升高（p<0.05）。 CVD 的传统危险因素（血压、胆固醇、吸烟习惯或肥胖）与 miR-21、miR-210 和 miR-222 之间没有相关性。 DIANA-mirPath 鉴定了 miR-21、miR-210 和 miR-222 的 611 个潜在基因靶标，通路分析表明低 VO2max 受试者的几个重要信号系统发生了变化。潜在的偏差涉及从非禁食个体采集血液，并且 8 个人在采样前 24 小时内进行了锻炼。总之，我们发现 miR-210、miR-21 和 miR-222 在 VO2max 较低的健康受试者中增加。这三个 miR 与其他健康相关变量以及传统 CVD 风险因素之间缺乏关联，表明这些 miR 可能有潜力作为健康水平和未来 CVD 的新的独立生物标志物。
Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent potential early markers of future cardiovascular disease (CVD). The aim of this study was to assess whether circulating microRNAs (miRs) are associated with VO2max-level in healthy individuals. In a screening study, 720 miRs were measured in serum samples from healthy individuals (40–45 yrs) with high (n = 12) or low (n = 12) VO2max matched for gender, age and physical activity. Candiate miRs were validated in a second cohort of subjects with high (n = 38) or low (n = 38) VO2max. miR-210 and miR-222 were found to be higher in the low VO2max-group (p<0.05). In addition, miR-21 was increased in male participants with low VO2max (p<0.05). There were no correlations between traditional risk factors for CVD (blood pressure, cholesterol, smoking habit, or obesity) and miR-21, miR-210 and miR-222. DIANA-mirPath identified 611 potential gene-targets of miR-21, miR-210 and miR-222, and pathway analysis indicated alterations in several important signaling systems in subjects with low VO2max. Potential bias involve that blood was collected from non-fasting individuals, and that 8 performed exercise within 24 h before sampling. In conclusion, we found that miR-210, miR-21, and miR-222 were increased in healthy subjects with low VO2max. The lack of association between these three miRs, and other fitness related variables as well as traditional CVD risk factors, suggests that these miRs may have a potential as new independent biomarkers of fitness level and future CVD.
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糖尿病性缺血性心力衰竭患者的microRNA失调。
影响因子：
7.7
作者：
Greco S;Fasanaro P;Castelvecchio S;D'Alessandra Y;Arcelli D;Di Donato M;Malavazos A;Capogrossi MC;Menicanti L;Martelli F
通讯作者：
Martelli F
影响因子：
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作者：
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通讯作者：
Schroen, Blanche
DOI：
10.1038/oby.2004.99
发表时间：
2004-05-01
期刊：
OBESITY RESEARCH
影响因子：
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作者：
Farrell, SW;Cheng, YLJ;Blair, SN
通讯作者：
Blair, SN
DOI：
10.1249/mss.0b013e318216ea50
发表时间：
2011-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
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作者：
Aspenes, Stian Thoresen;Nauman, Javaid;Wisloff, Ulrik
通讯作者：
Wisloff, Ulrik
影响因子：
5
作者：
Cheng, Yunhui;Liu, Xiaojun;Zhang, Shuo;Lin, Ying;Yang, Jian;Zhang, Chunxiang
通讯作者：
Zhang, Chunxiang