Food Insecurity, Memory, and Dementia Among US Adults Aged 50 Years and Older.
Food Insecurity, Memory, and Dementia Among US Adults Aged 50 Years and Older.
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DOI：
10.1001/jamanetworkopen.2023.44186
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发表时间：
2023-11-01
影响因子：
13.8
通讯作者：
Vable, Anusha M.
中科院分区：
文献类型：
--
作者：
Qian, Haobing;Khadka, Aayush;Martinez, Suzanna M.;Singh, Sonali;Brenowitz, Willa D.;Zeki Al Hazzouri, Adina;Hill-Jarrett, Tanisha G.;Glymour, M. Maria;Vable, Anusha M.
老年人中的食物不安全是否与随后更高的痴呆症风险和记忆力下降有关？在这项对7012名老年人进行的队列研究中，食物不安全与估计的痴呆症风险增加有关。食物不安全也与较低的记忆力分数和较快的记忆力衰退有关。这项研究的结果表明，老年人的食物不安全与较差的认知表现和较高的痴呆症风险有关。尽管现有的联邦计划增加了获得食物的机会，但食物不安全在美国老年人中很常见。食物不安全可能通过多种机制影响阿尔茨海默病和阿尔茨海默病相关痴呆，但几乎没有量化研究评估这种联系。研究老年人的食物不安全是否与晚年的认知结果有关。《美国健康与退休研究》对50岁及以上的美国居民进行的这项队列研究，仅限于2013年有食物不安全数据、2014至2018历年有认知结果数据的受访者。分析是在2023年6月1日至9月22日进行的。2013年的粮食不安全状况是使用经过验证的美国农业部6项家庭粮食安全模块进行评估的。受访者被归类为食品安全、低食品安全和极低食品安全。结果是痴呆症概率和记忆得分(标准化为1998个单位)，使用先前验证的算法在2014至2018年间每两年估计一次。广义估计方程适用于痴呆症风险和记忆得分的线性混合效应模型，通过截断权重的逆概率考虑了选择性磨损。调查对象为7012人(18 356人波)，平均年龄67.7(10.0)岁，女性4131人(58.9%)，非西班牙裔黑人1136人(16.2%)，非西班牙裔白人4849人(69.2%)，平均受教育年限13.0(3.0)年。与食物安全的老年人相比，经历低食物安全的老年人患痴呆症的几率更高(优势比，1.38；95%CI，1.15-1.67)，而经历非常低食物安全的老年人(优势比，1.37；95%CI，1.11-1.59)。低和极低的食物安全也与较低的记忆水平和较快的与年龄相关的记忆衰退有关。在这项对美国老年居民进行的队列研究中，食物不安全与痴呆症风险增加、记忆功能较差和记忆衰退更快相关。未来的研究需要检验解决食物不安全问题是否有益于大脑健康。这项队列研究考察了患有食物不安全的老年人的认知结果。
Is food insecurity among older adults associated with higher subsequent dementia risk and memory decline? In this cohort study of 7012 older adults, food insecurity was associated with an increased estimated dementia risk. Food insecurity was also associated with lower memory scores and faster memory decline. The findings of this study suggest that food insecurity among older adults is associated with worse cognitive performance and higher dementia risk. Despite existing federal programs to increase access to food, food insecurity is common among US older adults. Food insecurity may affect Alzheimer disease and Alzheimer disease–related dementias via multiple mechanisms, yet there is almost no quantitative research evaluating this association. To examine whether food insecurity in older adults is associated with later-life cognitive outcomes. This cohort study of US residents aged 50 years and older from the US Health and Retirement Study was restricted to respondents with food insecurity data in 2013 and cognitive outcome data between calendar years 2014 and 2018. Analyses were conducted from June 1 to September 22, 2023. Food insecurity status in 2013 was assessed using the validated US Department of Agriculture 6-item Household Food Security Module. Respondents were classified as being food secure, low food secure, and very low food secure. Outcomes were dementia probability and memory score (standardized to 1998 units), estimated biennially between 2014 and 2018 using a previously validated algorithm. Generalized estimation equations were fit for dementia risk and linear mixed-effects models for memory score, taking selective attrition into account through inverse probability of censoring weights. The sample consisted of 7012 participants (18 356 person-waves); mean (SD) age was 67.7 (10.0) years, 4131 (58.9%) were women, 1136 (16.2%) were non-Hispanic Black, 4849 (69.2%) were non-Hispanic White, and mean (SD) duration of schooling was 13.0 (3.0) years. Compared with food-secure older adults, experiencing low food security was associated with higher odds of dementia (odds ratio, 1.38; 95% CI, 1.15-1.67) as was experiencing very low food security (odds ratio, 1.37; 95% CI, 1.11-1.59). Low and very low food security was also associated with lower memory levels and faster age-related memory decline. In this cohort study of older US residents, food insecurity was associated with increased dementia risk, poorer memory function, and faster memory decline. Future studies are needed to examine whether addressing food insecurity may benefit brain health. This cohort study examines cognitive outcomes in older individuals with food insecurity.
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影响因子：
29
作者：
Gottesman, Rebecca F.;Albert, Marilyn S.;Knopman, David S.
通讯作者：
Knopman, David S.
影响因子：
4.8
作者：
Andersen, Andreas;Rieckmann, Andreas
通讯作者：
Rieckmann, Andreas
影响因子：
5.6
作者：
Glymour, M. Maria;Avendano, Mauricio;Berkman, Lisa F.
通讯作者：
Berkman, Lisa F.
DOI：
10.1136/bmj.n156
发表时间：
2021-02-25
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ackley SF;Zimmerman SC;Brenowitz WD;Tchetgen Tchetgen EJ;Gold AL;Manly JJ;Mayeda ER;Filshtein TJ;Power MC;Elahi FM;Brickman AM;Glymour MM
通讯作者：
Glymour MM
影响因子：
7.1
作者：
Gao, Xiang;Scott, Tammy;Tucker, Katherine L.
通讯作者：
Tucker, Katherine L.