Research on Water Bath Dynamic Cross-linking Properties of Bone Scaffold Made of Gelatin and Sodium Alginate
Research on Water Bath Dynamic Cross-linking Properties of Bone Scaffold Made of Gelatin and Sodium Alginate
复制标题
明胶海藻酸钠骨支架水浴动态交联性能研究
DOI：
10.19026/ajfst.5.3103
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Qingxi Hu
中科院分区：
文献类型：
--
作者：
Lulu Zheng;Y. Liu;Feifei Yan;Weihua Chen;Fuhua Zhang;Qingxi Hu
本研究提出了一种新的水浴动态交联方法，该方法在制备骨支架的过程中加入了交联过程。生物材料具有良好的生物相容性，但力学性能较差。因此，未交联的骨支架降解快，易收缩，不能满足组织工程支架的要求。明胶-海藻酸钠（SA）作为一种凝胶型支架材料，经钙离子交联后，可获得较好的力学性能。但由于Ca 2+离子与SA溶液发生反应，凝胶限制了Ca 2+离子在整个体系中的流动，使体系内部交联过程不均匀。实验结果表明，该方法制备的支架具有较高的孔隙率、含水量、较低的降解速率和较好的力学性能。
This study presents a novel water bath dynamic cross-linking method which involves cross-linking process when the bone scaffold is being manufactured. Biomaterial possesses good biocompatibility, but possesses poor mechanical properties. Thus, the uncross-linked bone scaffold usually degrades rapidly, contracts easily and can't meet the requirements of scaffold for tissue engineering. After being cross-linked by Ca 2+ ions, scaffold made of Gelatin and Sodium Alginate (SA), one kind of gel-type scaffolds, can present much better mechanical properties. However, Ca 2+ ions can react with SA solution and the gel can limit the flowing of Ca 2+ ions in the entire system, hence making cross-linking process uneven for the inner part. Applying the novel approach, the designed experiment verifies the scaffold can posses higher porosity, contain more water, has lower degradation rate and better mechanical properties.
影响因子：
14
作者：
Frohbergh, Michael E.;Katsman, Anna;Botta, Gregory R.;Lazarovici, Phillip;Schauer, Caroline L.;Wegst, Ulrike G. K.;Lelkes, Peter I.
通讯作者：
Lelkes, Peter I.