How does precursor RNA structure influence RNA processing and gene expression?
How does precursor RNA structure influence RNA processing and gene expression?
复制标题
前体RNA结构如何影响RNA处理和基因表达？
DOI：
10.1042/bsr20220149
复制
发表时间：
2023-03-31
影响因子：
4
通讯作者：
Lackey, Lela
中科院分区：
文献类型：
--
作者：
Herbert, Austin;Hatfield, Abigail;Lackey, Lela
RNA是一种基本的生物分子，在细胞内具有多种用途。由于其单链和灵活的性质，RNA自然折叠成复杂和动态的结构。最近的技术和计算进步产生了RNA结构数据的爆炸性增长。许多RNA结构具有调节和功能特性。由于新生RNA的丰度低且长度长，研究其结构特别具有挑战性，但它们的结构很重要，因为它们可以影响RNA的加工。前体RNA加工是决定成熟异构体组成和控制基因表达的一系列途径。在这篇综述中，我们审查了关于人类新生RNA结构的已知情况，以及RNA结构对前体RNA加工的影响。这些已知的结构为其他新生RNA的结构提供了例子，并显示了新的RNA结构可能如何影响RNA的加工，包括剪接和多聚腺苷化。RNA结构可以作为治疗疾病的靶点。
RNA is a fundamental biomolecule that has many purposes within cells. Due to its single-stranded and flexible nature, RNA naturally folds into complex and dynamic structures. Recent technological and computational advances have produced an explosion of RNA structural data. Many RNA structures have regulatory and functional properties. Studying the structure of nascent RNAs is particularly challenging due to their low abundance and long length, but their structures are important because they can influence RNA processing. Precursor RNA processing is a nexus of pathways that determines mature isoform composition and that controls gene expression. In this review, we examine what is known about human nascent RNA structure and the influence of RNA structure on processing of precursor RNAs. These known structures provide examples of how other nascent RNAs may be structured and show how novel RNA structures may influence RNA processing including splicing and polyadenylation. RNA structures can be targeted therapeutically to treat disease.
登录
查看更多内容
DOI：
10.1261/rna.077263.120
发表时间：
2020-12-11
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Bubenik JL;Hale M;McConnell O;Wang E;Swanson MS;Spitale R;Berglund JA
通讯作者：
Berglund JA
影响因子：
14.9
作者：
Saha K;Fernandez MM;Biswas T;Joseph S;Ghosh G
通讯作者：
Ghosh G
影响因子：
14.9
作者：
Buratti E;Dhir A;Lewandowska MA;Baralle FE
通讯作者：
Baralle FE
影响因子：
--
作者：
Corley M;Flynn RA;Blue SM;Yee BA;Chang HY;Yeo GW
通讯作者：
Yeo GW