Human Papillomavirus Vaccines: An Updated Review.

Human Papillomavirus Vaccines: An Updated Review.
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DOI:
10.3390/vaccines8030391
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发表时间:
2020-07-16
期刊:
影响因子:
7.8
通讯作者:
Du J
Du J
中科院分区:
医学3区
文献类型:
--
作者:
Cheng L;Wang Y;Du J

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人乳头瘤病毒(HPV)疫苗在过去十年中在许多国家推出,在减少HPV感染和相关疾病(如尖锐湿疣和癌前病变)方面显示出良好的效果。在这篇综述中,我们介绍了关于当前HPV疫苗的最新信息,重点是疫苗覆盖率和有效性。此外,还讨论了泛性别疫苗接种和目前的临床试验。目前,应作出更多努力来扩大疫苗的覆盖面,特别是在低收入和中等收入国家。提供有关HPV的教育和接种疫苗是实现这一目标的最重要方法之一。针对当前疫苗中未包括的HPV类型的疫苗是疫苗开发的下一个阶段。今后,应该跟踪和评估所有与HPV相关的癌症,如头颈癌和肛门癌,特别是在已经引入泛性别疫苗接种计划的国家。治疗性疫苗与其他癌症治疗相结合,应该继续进行研究。
Human papillomavirus (HPV) vaccines, which were introduced in many countries in the past decade, have shown promising results in decreasing HPV infection and related diseases, such as warts and precancerous lesions. In this review, we present the updated information about current HPV vaccines, focusing on vaccine coverage and efficacy. In addition, pan-gender vaccination and current clinical trials are also discussed. Currently, more efforts should be put into increasing the vaccine’s coverage, especially in low- and middle-income countries. Provision of education on HPV and vaccination is one of the most important methods to achieve this. Vaccines that target HPV types not included in current vaccines are the next stage in vaccine development. In the future, all HPV-related cancers, such as head and neck cancer, and anal cancer, should be tracked and evaluated, especially in countries that have introduced pan-gender vaccination programs. Therapeutic vaccines, in combination with other cancer treatments, should continue to be investigated.
接种男孩和女孩反对致癌人乳头瘤病毒的直接益处:贝叶斯证据合成。
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